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KRT10 keratin 10 [ Homo sapiens (human) ]

Gene ID: 3858, updated on 15-Sep-2022

Summary

Official Symbol
KRT10provided by HGNC
Official Full Name
keratin 10provided by HGNC
Primary source
HGNC:HGNC:6413
See related
Ensembl:ENSG00000186395 MIM:148080; AllianceGenome:HGNC:6413
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIE; EHK; K10; KPP; BCIE; CK10
Summary
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward skin (RPKM 7171.9) See more
Orthologs
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Genomic context

See KRT10 in Genome Data Viewer
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (40818117..40822614, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41682437..41686934, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38974369..38978866, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371776 Neighboring gene keratin 28 Neighboring gene KRT10 antisense RNA 1 Neighboring gene uncharacterized LOC105371777 Neighboring gene Sharpr-MPRA regulatory region 3631 Neighboring gene keratin 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of skin epidermis IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of skin epidermis NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in epidermis development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in keratinocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in morphogenesis of an epithelium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptide cross-linking IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epidermis development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein heterotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cornified envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in keratin filament IPI
Inferred from Physical Interaction
more info
PubMed 
located_in membrane HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
keratin, type I cytoskeletal 10
Names
CK-10
cytokeratin 10
keratin 10, type I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008405.2 RefSeqGene

    Range
    5000..9497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000421.5NP_000412.4  keratin, type I cytoskeletal 10 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC090283
    Consensus CDS
    CCDS11377.1
    UniProtKB/Swiss-Prot
    Q8N175
    Related
    ENSP00000269576.5, ENST00000269576.6
    Conserved Domains (1) summary
    pfam00038
    Location:145454
    Filament; Intermediate filament protein
  2. NM_001379366.1NP_001366295.1  keratin, type I cytoskeletal 10 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC090283
    UniProtKB/TrEMBL
    A0A1B0GVI3
    Related
    ENSP00000490524.2, ENST00000635956.2
    Conserved Domains (1) summary
    pfam00038
    Location:145454
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    40818117..40822614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    41682437..41686934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)