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KRT7 keratin 7 [ Homo sapiens (human) ]

Gene ID: 3855, updated on 1-Jun-2020

Summary

Official Symbol
KRT7provided by HGNC
Official Full Name
keratin 7provided by HGNC
Primary source
HGNC:HGNC:6445
See related
Ensembl:ENSG00000135480 MIM:148059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K7; CK7; SCL; K2C7
Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in thyroid (RPKM 146.2), placenta (RPKM 75.4) and 5 other tissues See more
Orthologs

Genomic context

See KRT7 in Genome Data Viewer
Location:
12q13.13
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52233243..52252667)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52626954..52642709)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 80 Neighboring gene long intergenic non-protein coding RNA 2874 Neighboring gene long intergenic non-protein coding RNA 592 Neighboring gene methyltransferase like 7A pseudogene 1 Neighboring gene KRT7 antisense RNA 1 Neighboring gene keratin 87 pseudogene Neighboring gene keratin 88 pseudogene Neighboring gene keratin 86 Neighboring gene keratin 81

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3625, MGC129731

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
keratinization TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 
keratin filament IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
keratin, type II cytoskeletal 7
Names
CK-7
cytokeratin 7
keratin 7, type II
keratin, 55K type II cytoskeletal
keratin, simple epithelial type I, K7
sarcolectin
type II mesothelial keratin K7
type-II keratin Kb7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012296.1 RefSeqGene

    Range
    5074..20752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005556.4NP_005547.3  keratin, type II cytoskeletal 7

    See identical proteins and their annotated locations for NP_005547.3

    Status: REVIEWED

    Source sequence(s)
    AC021066, BC002700, BE740515, BE744321
    Consensus CDS
    CCDS8822.1
    UniProtKB/Swiss-Prot
    P08729
    Related
    ENSP00000329243.5, ENST00000331817.6
    Conserved Domains (3) summary
    pfam00038
    Location:90402
    Filament; Intermediate filament protein
    pfam13312
    Location:1595
    DUF4081; Domain of unknown function (DUF4081)
    pfam16208
    Location:187
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    52233243..52252667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538325.2XP_011536627.1  keratin, type II cytoskeletal 7 isoform X1

    Conserved Domains (4) summary
    pfam00038
    Location:90402
    Filament; Intermediate filament protein
    pfam13312
    Location:1595
    DUF4081; Domain of unknown function (DUF4081)
    pfam16208
    Location:187
    Keratin_2_head; Keratin type II head
    pfam16888
    Location:142249
    DUF5082; Domain of unknown function (DUF5082)
  2. XM_017019294.1XP_016874783.1  keratin, type II cytoskeletal 7 isoform X2

RNA

  1. XR_001748700.2 RNA Sequence

  2. XR_001748699.2 RNA Sequence

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