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KRT4 keratin 4 [ Homo sapiens (human) ]

Gene ID: 3851, updated on 11-Oct-2020

Summary

Official Symbol
KRT4provided by HGNC
Official Full Name
keratin 4provided by HGNC
Primary source
HGNC:HGNC:6441
See related
Ensembl:ENSG00000170477 MIM:123940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K4; CK4; CK-4; CYK4; WSN1
Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward esophagus (RPKM 10134.3) See more
Orthologs

Genomic context

See KRT4 in Genome Data Viewer
Location:
12q13.13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52806549..52814116, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53200327..53207900, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 76 Neighboring gene keratin 3 Neighboring gene keratin 79 Neighboring gene keratin 78

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of keratin 4 (KRT4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: KRT79

Homology

Clone Names

  • FLJ31692

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
keratinization TAS
Traceable Author Statement
more info
 
negative regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
keratin filament IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
keratin, type II cytoskeletal 4
Names
cytokeratin 4
keratin 4, type II
type-II keratin Kb4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007380.1 RefSeqGene

    Range
    5436..13003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002272.4NP_002263.3  keratin, type II cytoskeletal 4

    Status: REVIEWED

    Source sequence(s)
    AC107016, AK299400, AW082111, DR423040
    Consensus CDS
    CCDS41787.2
    UniProtKB/TrEMBL
    B4DRS2
    Related
    ENSP00000448220.1, ENST00000551956.2
    Conserved Domains (3) summary
    pfam00038
    Location:136449
    Filament; Intermediate filament protein
    pfam02321
    Location:302419
    OEP; Outer membrane efflux protein
    pfam16208
    Location:14133
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    52806549..52814116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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