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KRT3 keratin 3 [ Homo sapiens (human) ]

Gene ID: 3850, updated on 9-Jul-2017
Official Symbol
KRT3provided by HGNC
Official Full Name
keratin 3provided by HGNC
Primary source
HGNC:HGNC:6440
See related
Ensembl:ENSG00000186442 MIM:148043; Vega:OTTHUMG00000169799
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K3; CK3
Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Orthologs
Location:
12q13.13
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (52789685..52796108, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53183469..53189892, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 2 binding protein pseudogene 2 Neighboring gene keratin 76 Neighboring gene keratin 4 Neighboring gene keratin 79

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Keratinization, organism-specific biosystem (from REACTOME)
    Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ95909

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural molecule activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
intermediate filament cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 
keratin filament TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
keratin, type II cytoskeletal 3
Names
65 kDa cytokeratin
CK-3
cytokeratin 3
keratin 3, type II
type-II keratin Kb3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008350.1 RefSeqGene

    Range
    5001..11424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057088.2NP_476429.2  keratin, type II cytoskeletal 3

    See identical proteins and their annotated locations for NP_476429.2

    Status: REVIEWED

    Source sequence(s)
    AC107016, AJ628418, BM672628, CV571376
    Consensus CDS
    CCDS44895.1
    UniProtKB/Swiss-Prot
    P12035
    Related
    ENSP00000413479.2, OTTHUMP00000242121, ENST00000417996.2, OTTHUMT00000405930
    Conserved Domains (3) summary
    pfam00038
    Location:197512
    Filament; Intermediate filament protein
    pfam16208
    Location:170194
    Keratin_2_head; Keratin type II head
    cl23720
    Location:425486
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

    Range
    52789685..52796108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    53150250..53156694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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