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Kash5 KASH domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 384619, updated on 8-Feb-2024

Summary

Official Symbol
Kash5provided by MGI
Official Full Name
KASH domain containing 5provided by MGI
Primary source
MGI:MGI:2687329
See related
Ensembl:ENSMUSG00000038292 AllianceGenome:MGI:2687329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1434; Ccdc155
Summary
Enables dynein complex binding activity and identical protein binding activity. Involved in cytoskeleton organization; spindle localization; and telomere localization. Acts upstream of or within double-strand break repair via homologous recombination; gamete generation; and homologous chromosome segregation. Located in chromosome; meiotic spindle pole; and nuclear outer membrane. Part of meiotic nuclear membrane microtubule tethering complex. Is expressed in spermatocyte. Orthologous to human KASH5 (KASH domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 31.9) and lung adult (RPKM 1.5) See more
Orthologs
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Genomic context

See Kash5 in Genome Data Viewer
Location:
7 B3; 7 29.17 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44833043..44854344, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45183619..45204919, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1733 Neighboring gene golgi-associated olfactory signaling regulator Neighboring gene STARR-seq mESC enhancer starr_18832 Neighboring gene parathyroid hormone 2 Neighboring gene predicted gene, 31097 Neighboring gene STARR-positive B cell enhancer ABC_E10438 Neighboring gene dickkopf-like 1 Neighboring gene TEA domain family member 2 Neighboring gene STARR-seq mESC enhancer starr_18834

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Clone Names

  • MGC60968

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dynein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromosome localization to nuclear envelope involved in homologous chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chromosome localization to nuclear envelope involved in homologous chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within meiotic telomere clustering IPI
Inferred from Physical Interaction
more info
PubMed 
acts_upstream_of_or_within oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spindle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spindle localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in telomere localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in telomere localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lateral element IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lateral element IDA
Inferred from Direct Assay
more info
PubMed 
part_of meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of meiotic nuclear membrane microtubule tethering complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in meiotic spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in meiotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein KASH5
Names
KASH domain-containing protein 5
coiled-coil domain containing 155
coiled-coil domain-containing protein 155
NP_958762.2
XP_006541031.1
XP_011249173.1
XP_017177818.1
XP_017177820.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201374.2NP_958762.2  protein KASH5

    See identical proteins and their annotated locations for NP_958762.2

    Status: VALIDATED

    Source sequence(s)
    AC149868
    Consensus CDS
    CCDS21234.2
    UniProtKB/Swiss-Prot
    E9QNS3, E9QQ69, Q80VJ8
    Related
    ENSMUSP00000113616.3, ENSMUST00000121017.5
    Conserved Domains (3) summary
    pfam14658
    Location:108175
    EF-hand_9; EF-hand domain
    pfam14662
    Location:227418
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cl12013
    Location:253415
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44833043..44854344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250871.3XP_011249173.1  protein KASH5 isoform X2

    Conserved Domains (2) summary
    pfam14658
    Location:38105
    EF-hand_9; EF-hand domain
    pfam14662
    Location:157347
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
  2. XM_017322329.2XP_017177818.1  protein KASH5 isoform X3

    Conserved Domains (2) summary
    pfam14658
    Location:77144
    EF-hand_9; EF-hand domain
    pfam14662
    Location:196371
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
  3. XM_006540968.4XP_006541031.1  protein KASH5 isoform X1

    Conserved Domains (2) summary
    pfam14658
    Location:77144
    EF-hand_9; EF-hand domain
    pfam14662
    Location:196386
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
  4. XM_017322331.3XP_017177820.1  protein KASH5 isoform X4

    Conserved Domains (2) summary
    pfam14658
    Location:77144
    EF-hand_9; EF-hand domain
    pfam14662
    Location:196305
    KASH_CCD; Coiled-coil region of CCDC155 or KASH

RNA

  1. XR_003946500.2 RNA Sequence

  2. XR_001785582.3 RNA Sequence