Format

Send to:

Choose Destination

Fndc5 fibronectin type III domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 384061, updated on 19-Aug-2018

Summary

Official Symbol
Fndc5provided by MGI
Official Full Name
fibronectin type III domain containing 5provided by MGI
Primary source
MGI:MGI:1917614
See related
Ensembl:ENSMUSG00000001334 Vega:OTTMUSG00000009621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PeP; Pxp; C87088; AI836596; 1500001L03Rik
Summary
This gene encodes a type I transmembrane protein containing fibronectin type III repeat. The encoded transmembrane protein undergoes proteolytic processing to generate a soluble hormone named irisin that is secreted into the bloodstream. The expression of this gene followed by the secretion of irisin from skeletal muscle is induced by exercise. The ectopic expression of the encoded protein in mice causes an elevation of irisin in blood and improves metabolic health. [provided by RefSeq, Jul 2016]
Expression
Biased expression in heart adult (RPKM 86.3), cerebellum adult (RPKM 47.9) and 6 other tissues See more
Orthologs

Genomic context

See Fndc5 in Genome Data Viewer
Location:
4; 4 D2.2
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (129136921..129144593)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (128814304..128821837)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene ring finger protein 19B Neighboring gene transmembrane protein 54 Neighboring gene hippocalcin Neighboring gene S100P binding protein Neighboring gene tyrosyl-tRNA synthetase Neighboring gene expressed sequence C77080

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • MGC129464, MGC129465

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hormone activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of brown fat cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
response to muscle activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
peroxisome IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fibronectin type III domain-containing protein 5
Names
fibronectin type III repeat-containing protein 2
peroxisomal protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027402.4NP_081678.1  fibronectin type III domain-containing protein 5 preproprotein

    See identical proteins and their annotated locations for NP_081678.1

    Status: REVIEWED

    Source sequence(s)
    AA003587, AI836596, AK005096, AL606977, BE861837, BG088140, BY265316, CX207206
    Consensus CDS
    CCDS18683.1
    UniProtKB/Swiss-Prot
    Q8K4Z2
    Related
    ENSMUSP00000099660.3, OTTMUSP00000010089, ENSMUST00000102600.3, OTTMUST00000022138
    Conserved Domains (2) summary
    cd00063
    Location:31121
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam16066
    Location:148200
    DUF4808; Domain of unknown function (DUF4808)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    129136921..129144593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503212.3XP_006503275.1  fibronectin type III domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006503275.1

    Conserved Domains (1) summary
    cd00063
    Location:62152
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Reference GRCm38.p4 NOD/MrkTac

Genomic

  1. NT_187023.1 Reference GRCm38.p4 NOD/MrkTac

    Range
    739662..747201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center