U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Aim2 absent in melanoma 2 [ Mus musculus (house mouse) ]

Gene ID: 383619, updated on 20-Feb-2024

Summary

Official Symbol
Aim2provided by MGI
Official Full Name
absent in melanoma 2provided by MGI
Primary source
MGI:MGI:2686159
See related
Ensembl:ENSMUSG00000037860 AllianceGenome:MGI:2686159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1313; Ifi210
Summary
Enables double-stranded DNA binding activity and identical protein binding activity. Involved in positive regulation of macromolecule metabolic process; pyroptosis; and regulation of defense response. Acts upstream of or within cellular response to interferon-beta. Located in cytoplasm. Part of AIM2 inflammasome complex. Orthologous to human AIM2 (absent in melanoma 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 1.0), CNS E11.5 (RPKM 0.8) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Aim2 in Genome Data Viewer
Location:
1 H3; 1 80.33 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173177105..173293606)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173349547..173466040)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene mucosal pentraxin 2 Neighboring gene STARR-seq mESC enhancer starr_03074 Neighboring gene STARR-seq mESC enhancer starr_03075 Neighboring gene atypical chemokine receptor 1 (Duffy blood group) Neighboring gene cell adhesion molecule 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:175328755-175329056 Neighboring gene STARR-seq mESC enhancer starr_03076 Neighboring gene nuclear encoded tRNA arginine 5 (anticodon TCT) Neighboring gene STARR-positive B cell enhancer ABC_E2021 Neighboring gene STARR-seq mESC enhancer starr_03077 Neighboring gene STARR-positive B cell enhancer ABC_E1574 Neighboring gene STARR-seq mESC enhancer starr_03078 Neighboring gene STARR-positive B cell enhancer ABC_E5856 Neighboring gene STARR-positive B cell enhancer ABC_E11107 Neighboring gene STARR-seq mESC enhancer starr_03079 Neighboring gene interferon activated gene 206 Neighboring gene STARR-seq mESC enhancer starr_03080 Neighboring gene STARR-positive B cell enhancer ABC_E10059 Neighboring gene STARR-positive B cell enhancer ABC_E4392 Neighboring gene interferon activated gene 214

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables pattern recognition receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pattern recognition receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in AIM2 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in AIM2 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in activation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in brain development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in defense response to virus NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron cellular homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pattern recognition receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-1 beta production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in pyroptosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pyroptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in pyroptosis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in pyroptosome complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of behavior IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of AIM2 inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of AIM2 inflammasome complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of AIM2 inflammasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of canonical inflammasome complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interferon-inducible protein AIM2
Names
ifi-210
interferon-inducible protein 210
interferon-inducible protein p210

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013779.2NP_001013801.2  interferon-inducible protein AIM2

    See identical proteins and their annotated locations for NP_001013801.2

    Status: VALIDATED

    Source sequence(s)
    AC084073, AK050724, DT921984
    Consensus CDS
    CCDS15529.2
    UniProtKB/Swiss-Prot
    Q91VJ1
    Related
    ENSMUSP00000132253.3, ENSMUST00000166137.3
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    173177105..173293606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166274.1XP_036022167.1  interferon-inducible protein AIM2 isoform X3

    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156276
    HIN; HIN-200/IF120x domain
  2. XM_036166269.1XP_036022162.1  interferon-inducible protein AIM2 isoform X3

    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156276
    HIN; HIN-200/IF120x domain
  3. XM_036166268.1XP_036022161.1  interferon-inducible protein AIM2 isoform X2

    Conserved Domains (2) summary
    cd08305
    Location:1058
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:125290
    HIN; HIN-200/IF120x domain
  4. XM_036166266.1XP_036022159.1  interferon-inducible protein AIM2 isoform X2

    Conserved Domains (2) summary
    cd08305
    Location:1058
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:125290
    HIN; HIN-200/IF120x domain
  5. XM_036166267.1XP_036022160.1  interferon-inducible protein AIM2 isoform X2

    Conserved Domains (2) summary
    cd08305
    Location:1058
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:125290
    HIN; HIN-200/IF120x domain
  6. XM_036166259.1XP_036022152.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  7. XM_036166264.1XP_036022157.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  8. XM_036166265.1XP_036022158.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  9. XM_006496926.3XP_006496989.1  interferon-inducible protein AIM2 isoform X1

    See identical proteins and their annotated locations for XP_006496989.1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  10. XM_030255241.2XP_030111101.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  11. XM_036166247.1XP_036022140.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  12. XM_036166244.1XP_036022137.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  13. XM_036166245.1XP_036022138.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  14. XM_036166238.1XP_036022131.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  15. XM_036166249.1XP_036022142.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Related
    ENSMUSP00000119465.2, ENSMUST00000147604.8
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  16. XM_017321496.3XP_017176985.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  17. XM_017321486.3XP_017176975.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  18. XM_017321501.3XP_017176990.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  19. XM_017321492.3XP_017176981.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  20. XM_017321498.3XP_017176987.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  21. XM_011238835.3XP_011237137.1  interferon-inducible protein AIM2 isoform X1

    See identical proteins and their annotated locations for XP_011237137.1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  22. XM_011238842.3XP_011237144.1  interferon-inducible protein AIM2 isoform X1

    See identical proteins and their annotated locations for XP_011237144.1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  23. XM_006496919.4XP_006496982.1  interferon-inducible protein AIM2 isoform X1

    See identical proteins and their annotated locations for XP_006496982.1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  24. XM_036166246.1XP_036022139.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  25. XM_036166248.1XP_036022141.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  26. XM_011238831.4XP_011237133.1  interferon-inducible protein AIM2 isoform X1

    See identical proteins and their annotated locations for XP_011237133.1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  27. XM_036166260.1XP_036022153.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  28. XM_036166262.1XP_036022155.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  29. XM_017321505.3XP_017176994.1  interferon-inducible protein AIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ1
    Conserved Domains (2) summary
    cd08305
    Location:1079
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:156321
    HIN; HIN-200/IF120x domain
  30. XM_030255292.2XP_030111152.1  interferon-inducible protein AIM2 isoform X2

    Conserved Domains (2) summary
    cd08305
    Location:1058
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:125290
    HIN; HIN-200/IF120x domain
  31. XM_006496929.3XP_006496992.1  interferon-inducible protein AIM2 isoform X4

    Conserved Domains (1) summary
    pfam02760
    Location:13178
    HIN; HIN-200/IF120x domain