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Kif28 kinesin family member 28 [ Mus musculus (house mouse) ]

Gene ID: 383592, updated on 8-Feb-2024

Summary

Official Symbol
Kif28provided by MGI
Official Full Name
kinesin family member 28provided by MGI
Primary source
MGI:MGI:2686151
See related
Ensembl:ENSMUSG00000087236 AllianceGenome:MGI:2686151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1305; Kif28p
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in mitochondrion organization and organelle transport along microtubule. Predicted to be located in mitochondrial membrane. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Orthologous to human KIF28P (kinesin family member 28, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

Location:
1 H4; 1 83.62 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (179522602..179572825, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (179695037..179745200, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2590 Neighboring gene STARR-positive B cell enhancer ABC_E4399 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:181508880-181509063 Neighboring gene consortin, connexin sorting protein Neighboring gene STARR-seq mESC enhancer starr_03181 Neighboring gene STARR-seq mESC enhancer starr_03183 Neighboring gene saccharopine dehydrogenase (putative) Neighboring gene AT hook containing transcription factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E3340 Neighboring gene STARR-positive B cell enhancer ABC_E5865 Neighboring gene STARR-seq mESC enhancer starr_03185 Neighboring gene predicted gene, 31668 Neighboring gene STARR-seq mESC enhancer starr_03186 Neighboring gene CDC42 binding protein kinase alpha Neighboring gene STARR-seq mESC enhancer starr_03187 Neighboring gene predicted gene, 50608

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in organelle transport along microtubule ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinesin-like protein KIF28
Names
kinesin-like protein 6
kinesin-like protein KIF28P

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370897.2NP_001357826.1  kinesin-like protein KIF28

    Status: VALIDATED

    Source sequence(s)
    AC113977, AC122411
    UniProtKB/TrEMBL
    R4GML7
    Related
    ENSMUSP00000118935.5, ENSMUST00000131716.4
    Conserved Domains (3) summary
    cd00060
    Location:440537
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl22853
    Location:15370
    Motor_domain; Myosin and Kinesin motor domain
    pfam12423
    Location:655693
    KIF1B; Kinesin protein 1B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    179522602..179572825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)