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CPT2 Carnitine palmitoyltransferase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38355, updated on 18-Sep-2024

Summary

Official Symbol
CPT2provided by FlyBase
Official Full Name
Carnitine palmitoyltransferase 2provided by FlyBase
Primary source
FLYBASE:FBgn0035383
Locus tag
Dmel_CG2107
See related
AllianceGenome:FB:FBgn0035383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2107; cpt; Cpt2; dCPT2; Dmel\CG2107; SD01848p
Summary
Predicted to enable carnitine O-palmitoyltransferase activity. Involved in several processes, including fatty acid beta-oxidation; ketone body biosynthetic process; and triglyceride homeostasis. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in brain disease; lipid metabolism disorder; and muscular disease. Orthologous to human CPT2 (carnitine palmitoyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See CPT2 in Genome Data Viewer
Location:
63A2-63A2; 3-5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2981022..2983551)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2981022..2983551)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Odorant receptor 63a Neighboring gene long non-coding RNA:CR44530 Neighboring gene uncharacterized protein Neighboring gene FMRFamide Receptor

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables carnitine O-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ketone body biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
carnitine palmitoyltransferase 2
Names
CG2107-PA
CPT2-PA
NP_647756.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    2981022..2983551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139499.3NP_647756.1  carnitine palmitoyltransferase 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647756.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQY1, Q9VZW7
    Related
    FBpp0072848
    Conserved Domains (1) summary
    pfam00755
    Location:45655
    Carn_acyltransf; Choline/Carnitine o-acyltransferase