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KIFC1 kinesin family member C1 [ Homo sapiens (human) ]

Gene ID: 3833, updated on 10-Oct-2019

Summary

Official Symbol
KIFC1provided by HGNC
Official Full Name
kinesin family member C1provided by HGNC
Primary source
HGNC:HGNC:6389
See related
Ensembl:ENSG00000237649 MIM:603763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSET; KNSL2
Expression
Broad expression in bone marrow (RPKM 10.5), lymph node (RPKM 9.0) and 15 other tissues See more
Orthologs

Genomic context

See KIFC1 in Genome Data Viewer
Location:
6p21.32
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (33391524..33410226)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33359301..33377701)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene LYPLA2 pseudogene 1 Neighboring gene ribosomal protein L35a pseudogene 4 Neighboring gene ribosomal protein L12 pseudogene 1 Neighboring gene PHD finger protein 1 Neighboring gene synaptic Ras GTPase activating protein 1 Neighboring gene cutA divalent cation tolerance homolog Neighboring gene microRNA 5004

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates KIFC1 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1202, MGC149736, MGC149737

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic sister chromatid segregation NAS
Non-traceable Author Statement
more info
PubMed 
mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIFC1
Names
kinesin-like 2
kinesin-like protein 2
kinesin-related protein HSET

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002263.4NP_002254.2  kinesin-like protein KIFC1

    See identical proteins and their annotated locations for NP_002254.2

    Status: VALIDATED

    Source sequence(s)
    AI990093, BC063567, BE885900
    Consensus CDS
    CCDS34430.1
    UniProtKB/Swiss-Prot
    Q9BW19
    UniProtKB/TrEMBL
    A0A024RCS7
    Related
    ENSP00000393963.2, ENST00000428849.7
    Conserved Domains (2) summary
    cd01366
    Location:308665
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:138312
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    33391524..33410226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010837.1XP_016866326.1  kinesin-like protein KIFC1 isoform X3

    Conserved Domains (5) summary
    smart00129
    Location:269620
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01366
    Location:267620
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam16796
    Location:256276
    Microtub_bd; Microtubule binding
    cl01090
    Location:174227
    SlyX; SlyX
    cl02488
    Location:104253
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  2. XM_011514585.1XP_011512887.1  kinesin-like protein KIFC1 isoform X2

    See identical proteins and their annotated locations for XP_011512887.1

    Conserved Domains (5) summary
    smart00129
    Location:310666
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01366
    Location:308659
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam16796
    Location:297317
    Microtub_bd; Microtubule binding
    cl01090
    Location:215268
    SlyX; SlyX
    cl02488
    Location:145294
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  3. XM_011514587.2XP_011512889.1  kinesin-like protein KIFC1 isoform X4

    See identical proteins and their annotated locations for XP_011512889.1

    Conserved Domains (1) summary
    cl22853
    Location:250405
    Motor_domain; Myosin and Kinesin motor domain
  4. XM_017010836.1XP_016866325.1  kinesin-like protein KIFC1 isoform X1

    Conserved Domains (5) summary
    smart00129
    Location:310661
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01366
    Location:308661
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam16796
    Location:297317
    Microtub_bd; Microtubule binding
    cl01090
    Location:215268
    SlyX; SlyX
    cl02488
    Location:145294
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    4586231..4604282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    4840518..4858594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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