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Rrm2b ribonucleotide reductase M2 B (TP53 inducible) [ Mus musculus (house mouse) ]

Gene ID: 382985, updated on 9-Mar-2023

Summary

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Official Symbol
Rrm2bprovided by MGI
Official Full Name
ribonucleotide reductase M2 B (TP53 inducible)provided by MGI
Primary source
MGI:MGI:2155865
See related
Ensembl:ENSMUSG00000022292 AllianceGenome:MGI:2155865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p53R2
Summary
Enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Acts upstream of or within several processes, including mitochondrial DNA replication; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and nucleoside phosphate metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 3.1), frontal lobe adult (RPKM 2.6) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Rrm2b in Genome Data Viewer
Location:
15; 15 B3.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (37924196..37961363, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (37923952..37961119, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19, pseudogene 5 Neighboring gene predicted gene, 35019 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene predicted gene, 49085 Neighboring gene ubiquitin protein ligase E3 component n-recognin 5 Neighboring gene predicted gene, 22353

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ribonucleotide reductase: In-vitro S-glutathionylation of R2 and p53R2 subunits of mammalian class I ribonucleotide reductase protein. Chatterji A, et al. Mol Biol Rep, 2021 Nov. PMID 34599703
  2. Rrm2b deletion causes mitochondrial metabolic defects in renal tubules. Chen YF, et al. Sci Rep, 2019 Sep 13. PMID 31519977, Free PMC Article
  3. Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer. Xue L, et al. Am J Transl Res, 2018. PMID 30662615, Free PMC Article
  4. Rapid development of glomerular injury and renal failure in mice lacking p53R2. Powell DR, et al. Pediatr Nephrol, 2005 Mar. PMID 15723268
  5. Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms. Chang L, et al. Cell Rep, 2013 May 30. PMID 23643536, Free PMC Article

See all (29) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ribonucleotide reductase: In-vitro S-glutathionylation of R2 and p53R2 subunits of mammalian class I ribonucleotide reductase protein.
    Title: Ribonucleotide reductase: In-vitro S-glutathionylation of R2 and p53R2 subunits of mammalian class I ribonucleotide reductase protein.
  2. Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.
    Title: Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.
  3. Rrm2b deletion causes mitochondrial metabolic defects in renal tubules.
    Title: Rrm2b deletion causes mitochondrial metabolic defects in renal tubules.
  4. Rrm2b plays a crucial role in maintaining chromosomal stability and preventing chronic-inflammation-associated tumorigenesis.
    Title: Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms.
  5. Rrm2b deficiency caused higher rates of spontaneous mutation in the kidneys of Rrm2b-/- mice. p53R2 has a pivotal role in maintaining dNTP levels for repair of DNA in resting cells.
    Title: Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 2'-deoxyribonucleotide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA synthesis involved in DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within deoxyribonucleoside triphosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in deoxyribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within deoxyribonucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitochondrial DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G0 to G1 transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of G0 to G1 transition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within renal system process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribonucleoside diphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IC
Inferred by Curator
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribonucleoside-diphosphate reductase subunit M2 B
Names
TP53-inducible ribonucleotide reductase M2 B
p53-inducible ribonucleotide reductase small subunit 2-like protein
NP_001343951.1
NP_001343952.1
NP_955770.1
XP_011243663.1
XP_036015374.1
XP_036015375.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357022.2 → NP_001343951.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122291
    Conserved Domains (1) summary
    cl00264
    Location:18 → 337
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

  2. NM_001357023.2 → NP_001343952.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122291
    Conserved Domains (1) summary
    cl00264
    Location:1 → 297
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

  3. NM_001416546.1 → NP_001403475.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122291

  4. NM_001416547.1 → NP_001403476.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122291

  5. NM_001416548.1 → NP_001403477.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122291

  6. NM_001416549.1 → NP_001403478.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC122291

  7. NM_001416550.1 → NP_001403479.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC122291

  8. NM_001416551.1 → NP_001403480.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC122291

  9. NM_001416552.1 → NP_001403481.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC122291

  10. NM_199476.2 → NP_955770.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 1

    See identical proteins and their annotated locations for NP_955770.1

    Status: VALIDATED

    Source sequence(s)
    AC122291
    Consensus CDS
    CCDS27437.1
    UniProtKB/Swiss-Prot
    Q6PEE3
    UniProtKB/TrEMBL
    A0A8C6N4L2
    Related
    ENSMUSP00000022901.10, ENSMUST00000022901.16
    Conserved Domains (1) summary
    cl00264
    Location:32 → 351
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

RNA

  1. NR_184224.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122291

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    37924196..37961363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159481.1 → XP_036015374.1  ribonucleoside-diphosphate reductase subunit M2 B isoform X2

    Conserved Domains (1) summary
    cl00264
    Location:7 → 203
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

  2. XM_036159482.1 → XP_036015375.1  ribonucleoside-diphosphate reductase subunit M2 B isoform X2

    Conserved Domains (1) summary
    cl00264
    Location:7 → 203
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

  3. XM_011245361.4 → XP_011243663.1  ribonucleoside-diphosphate reductase subunit M2 B isoform X1

    Conserved Domains (1) summary
    cl00264
    Location:32 → 194
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

RNA

  1. XR_004938849.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PEE3.1 GenPept UniProtKB/Swiss-Prot:Q6PEE3

Gene LinkOut

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