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Rrm2b ribonucleotide reductase M2 B (TP53 inducible) [ Mus musculus (house mouse) ]

Gene ID: 382985, updated on 6-Jun-2024

Summary

Official Symbol
Rrm2bprovided by MGI
Official Full Name
ribonucleotide reductase M2 B (TP53 inducible)provided by MGI
Primary source
MGI:MGI:2155865
See related
Ensembl:ENSMUSG00000022292 AllianceGenome:MGI:2155865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p53R2
Summary
Enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Acts upstream of or within several processes, including mitochondrial DNA replication; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and nucleoside phosphate metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 3.1), frontal lobe adult (RPKM 2.6) and 24 other tissues See more
Orthologs
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Genomic context

See Rrm2b in Genome Data Viewer
Location:
15 B3.1; 15 15.1 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (37924196..37961562, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (37923952..37961119, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38432 Neighboring gene ribosomal protein S19, pseudogene 5 Neighboring gene predicted gene, 35019 Neighboring gene STARR-positive B cell enhancer ABC_E7364 Neighboring gene STARR-positive B cell enhancer mm9_chr15:37889822-37890123 Neighboring gene STARR-positive B cell enhancer ABC_E9416 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene predicted gene, 49085 Neighboring gene ubiquitin protein ligase E3 component n-recognin 5 Neighboring gene STARR-seq mESC enhancer starr_38435 Neighboring gene STARR-seq mESC enhancer starr_38437 Neighboring gene predicted gene, 22353 Neighboring gene predicted gene, 35081

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in 2'-deoxyribonucleotide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA synthesis involved in DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within deoxyribonucleoside triphosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in deoxyribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within deoxyribonucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrial DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of G0 to G1 transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of G0 to G1 transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within renal system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribonucleoside diphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IC
Inferred by Curator
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribonucleoside-diphosphate reductase subunit M2 B
Names
TP53-inducible ribonucleotide reductase M2 B
p53-inducible ribonucleotide reductase small subunit 2-like protein
NP_001343951.1
NP_001343952.1
NP_001403475.1
NP_001403476.1
NP_001403477.1
NP_001403478.1
NP_001403479.1
NP_001403480.1
NP_001403481.1
NP_955770.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357022.2NP_001343951.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122291
    UniProtKB/TrEMBL
    D3Z2A4
    Conserved Domains (1) summary
    cl00264
    Location:18337
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
  2. NM_001357023.2NP_001343952.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122291
    UniProtKB/TrEMBL
    D3Z2A4
    Conserved Domains (1) summary
    cl00264
    Location:1297
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
  3. NM_001416546.1NP_001403475.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122291
  4. NM_001416547.1NP_001403476.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122291
    UniProtKB/TrEMBL
    D3Z2A4
  5. NM_001416548.1NP_001403477.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122291
  6. NM_001416549.1NP_001403478.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC122291
  7. NM_001416550.1NP_001403479.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC122291
  8. NM_001416551.1NP_001403480.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC122291
  9. NM_001416552.1NP_001403481.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC122291
  10. NM_199476.2NP_955770.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 1

    See identical proteins and their annotated locations for NP_955770.1

    Status: VALIDATED

    Source sequence(s)
    AC122291
    Consensus CDS
    CCDS27437.1
    UniProtKB/Swiss-Prot
    Q6PEE3
    UniProtKB/TrEMBL
    D3Z2A4
    Related
    ENSMUSP00000022901.10, ENSMUST00000022901.16
    Conserved Domains (1) summary
    cl00264
    Location:32351
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

RNA

  1. NR_184224.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122291

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    37924196..37961562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)