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Kcnf1 potassium voltage-gated channel, subfamily F, member 1 [ Mus musculus (house mouse) ]

Gene ID: 382571, updated on 18-Sep-2024

Summary

Official Symbol
Kcnf1provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily F, member 1provided by MGI
Primary source
MGI:MGI:2687399
See related
Ensembl:ENSMUSG00000051726 AllianceGenome:MGI:2687399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kv5.1; Gm1182
Summary
Predicted to enable voltage-gated potassium channel activity. Involved in non-motile cilium assembly. Located in ciliary base. Is expressed in heart. Orthologous to human KCNF1 (potassium voltage-gated channel modifier subfamily F member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Kcnf1 in Genome Data Viewer
Location:
12 A1.1; 12 8.04 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (17222101..17226551, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (17172100..17176888, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31651 Neighboring gene STARR-positive B cell enhancer ABC_E7121 Neighboring gene solute carrier family 66 member 3 Neighboring gene STARR-positive B cell enhancer ABC_E11504 Neighboring gene ciliary microtubule inner protein 5 Neighboring gene STARR-seq mESC enhancer starr_31652 Neighboring gene STARR-seq mESC enhancer starr_31653 Neighboring gene STARR-seq mESC enhancer starr_31654 Neighboring gene predicted gene, 36568 Neighboring gene predicted gene 10054

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC62472

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in ciliary base IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily F member 1
Names
voltage-gated potassium channel subunit Kv5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201531.5NP_963289.3  potassium voltage-gated channel subfamily F member 1

    Status: VALIDATED

    Source sequence(s)
    AC159312
    Consensus CDS
    CCDS25825.2
    UniProtKB/Swiss-Prot
    Q7TSH7
    Related
    ENSMUSP00000131480.3, ENSMUST00000170580.3
    Conserved Domains (2) summary
    cd18381
    Location:23138
    BTB_POZ_Kv5_KCNF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels
    pfam00520
    Location:181417
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    17222101..17226551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)