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Jade3 jade family PHD finger 3 [ Mus musculus (house mouse) ]

Gene ID: 382207, updated on 14-Feb-2023

Summary

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Official Symbol
Jade3provided by MGI
Official Full Name
jade family PHD finger 3provided by MGI
Primary source
MGI:MGI:2148019
See related
Ensembl:ENSMUSG00000037315 AllianceGenome:MGI:2148019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Phf16; mKIAA0215; 5730598B06
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in histone acetylation. Predicted to be part of histone acetyltransferase complex. Is expressed in several structures, including alimentary system; genitourinary system; liver; nose; and respiratory system. Orthologous to human JADE3 (jade family PHD finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 22.3), CNS E18 (RPKM 3.8) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Jade3 in Genome Data Viewer
Location:
X; X A1.3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20291277..20386178)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20425312..20519939)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene retinitis pigmentosa 2 homolog Neighboring gene transcription initiation factor IIA subunit 1-like Neighboring gene high mobility group box 2 pseudogene Neighboring gene ubiquitin-like modifier activating enzyme 3 pseudogene Neighboring gene regucalcin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of Phf16 and Pnpla3 as new adipogenic factors regulated by phytochemicals. Chang SH, et al. J Cell Biochem, 2019 Mar. PMID 30272815, Free PMC Article
  2. Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development. Tzouanacou E, et al. Mol Cell Biol, 2003 Dec. PMID 14612400, Free PMC Article
  3. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in histone H4-K12 acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in histone H4-K5 acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in histone H4-K8 acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in histone modification ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein Jade-3
Names
PHD finger protein 16
jade family PHD finger protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289684.2 → NP_001276613.1  protein Jade-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672073, BX294384
    Conserved Domains (2) summary
    pfam10513
    Location:3 → 74
    EPL1; Enhancer of polycomb-like
    cl22851
    Location:152 → 262
    PHD_SF; PHD finger superfamily

  2. NM_001406239.1 → NP_001393168.1  protein Jade-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672073, BX294384

  3. NM_001406240.1 → NP_001393169.1  protein Jade-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672073, BX294384

  4. NM_001406241.1 → NP_001393170.1  protein Jade-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672073, BX294384
    UniProtKB/Swiss-Prot
    Q6ZQG2

  5. NM_199317.3 → NP_955021.3  protein Jade-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672073, BX294384
    Consensus CDS
    CCDS30042.2
    UniProtKB/Swiss-Prot
    Q6ZQG2
    Related
    ENSMUSP00000111042.6, ENSMUST00000115384.9

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    20291277..20386178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247477.3 → XP_011245779.1  protein Jade-3 isoform X1

    Conserved Domains (3) summary
    COG5141
    Location:165 → 536
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    pfam10513
    Location:74 → 204
    EPL1; Enhancer of polycomb-like
    cl22851
    Location:282 → 392
    PHD_SF; PHD finger superfamily

  2. XM_030251375.2 → XP_030107235.1  protein Jade-3 isoform X2

    Conserved Domains (3) summary
    COG5141
    Location:139 → 510
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    pfam10513
    Location:78 → 178
    EPL1; Enhancer of polycomb-like
    cl22851
    Location:256 → 366
    PHD_SF; PHD finger superfamily

  3. XM_011247476.2 → XP_011245778.1  protein Jade-3 isoform X1

    Conserved Domains (3) summary
    COG5141
    Location:165 → 536
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    pfam10513
    Location:74 → 204
    EPL1; Enhancer of polycomb-like
    cl22851
    Location:282 → 392
    PHD_SF; PHD finger superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IE82.1 GenPept UniProtKB/Swiss-Prot:Q6IE82

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