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Prdm10 PR domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 382066, updated on 25-May-2024

Summary

Official Symbol
Prdm10provided by MGI
Official Full Name
PR domain containing 10provided by MGI
Primary source
MGI:MGI:2682952
See related
Ensembl:ENSMUSG00000042496 AllianceGenome:MGI:2682952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1112; tristanin
Summary
Predicted to enable DNA binding activity; metal ion binding activity; and methyltransferase activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within methylation. Predicted to be located in chromatin. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal medulla; alimentary system; central nervous system; embryo mesenchyme; and genitourinary system. Orthologous to human PRDM10 (PR/SET domain 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 3.0), CNS E14 (RPKM 3.0) and 28 other tissues See more
Orthologs
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Genomic context

See Prdm10 in Genome Data Viewer
Location:
9 A4; 9 16.77 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (31187406..31293027)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (31276110..31381731)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23693 Neighboring gene predicted gene, 53544 Neighboring gene predicted gene 7244 Neighboring gene STARR-seq mESC enhancer starr_23695 Neighboring gene predicted gene, 51733 Neighboring gene predicted gene 10910 Neighboring gene STARR-seq mESC enhancer starr_23697 Neighboring gene STARR-seq mESC enhancer starr_23701 Neighboring gene RIKEN cDNA 1700023A20 gene Neighboring gene STARR-positive B cell enhancer ABC_E9326 Neighboring gene nuclear factor related to kappa B binding protein Neighboring gene STARR-positive B cell enhancer ABC_E8852

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC73898

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
PR domain zinc finger protein 10
Names
PR domain-containing protein 10
NP_001355774.1
NP_001355775.1
NP_001398366.1
NP_001398367.1
NP_955019.1
XP_006510528.1
XP_006510529.1
XP_006510531.1
XP_006510532.1
XP_006510533.1
XP_006510534.1
XP_011240870.1
XP_030100292.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368845.2NP_001355774.1  PR domain zinc finger protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC167244, CT025678
    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (7) summary
    PRK03427
    Location:9091007
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:612632
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:638660
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:568593
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399504
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins
  2. NM_001368846.2NP_001355775.1  PR domain zinc finger protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC167244, CT025678
    UniProtKB/TrEMBL
    A0A1L1SS03
    Related
    ENSMUSP00000149526.2, ENSMUST00000215499.2
    Conserved Domains (7) summary
    PRK03427
    Location:9051003
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:608628
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:634656
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:564589
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399504
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins
  3. NM_001411437.1NP_001398366.1  PR domain zinc finger protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC167244
  4. NM_001411438.1NP_001398367.1  PR domain zinc finger protein 10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC167244, CT025678
  5. NM_199315.2NP_955019.1  PR domain zinc finger protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC167244, CT025678
    Consensus CDS
    CCDS90529.1
    Related
    ENSMUSP00000112588.2, ENSMUST00000117389.8
    Conserved Domains (2) summary
    pfam18445
    Location:167194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197317
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    31187406..31293027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510471.4XP_006510534.1  PR domain zinc finger protein 10 isoform X6

    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (8) summary
    PRK03427
    Location:789887
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:520540
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:518540
    zf-C2H2; Zinc finger, C2H2 type
    pfam12171
    Location:351370
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:504527
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399504
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins
  2. XM_006510468.4XP_006510531.1  PR domain zinc finger protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (7) summary
    PRK03427
    Location:901999
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:604624
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:630652
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:560585
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399496
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins
  3. XM_030244432.1XP_030100292.1  PR domain zinc finger protein 10 isoform X7

    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (8) summary
    PRK03427
    Location:781879
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:512532
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:510532
    zf-C2H2; Zinc finger, C2H2 type
    pfam12171
    Location:351370
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:496519
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399496
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins
  4. XM_006510470.4XP_006510533.1  PR domain zinc finger protein 10 isoform X5

    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (8) summary
    PRK03427
    Location:841939
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:544564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:570592
    zf-C2H2; Zinc finger, C2H2 type
    pfam12171
    Location:283302
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:500525
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:331436
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167194
    zf_PR_Knuckle; PR zinc knuckle motif
    cl40432
    Location:197260
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
  5. XM_006510469.4XP_006510532.1  PR domain zinc finger protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (7) summary
    PRK03427
    Location:884982
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:587607
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:613635
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:543568
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:374479
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:142169
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:172303
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins
  6. XM_011242568.3XP_011240870.1  PR domain zinc finger protein 10 isoform X8

    Conserved Domains (7) summary
    COG5048
    Location:553629
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:526546
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:351370
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:568593
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399504
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins
  7. XM_006510466.4XP_006510529.1  PR domain zinc finger protein 10 isoform X1

    See identical proteins and their annotated locations for XP_006510529.1

    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (7) summary
    PRK03427
    Location:9091007
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:612632
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:638660
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:568593
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399504
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins
  8. XM_006510465.4XP_006510528.1  PR domain zinc finger protein 10 isoform X1

    See identical proteins and their annotated locations for XP_006510528.1

    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (7) summary
    PRK03427
    Location:9091007
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:612632
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:638660
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:568593
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399504
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins

RNA

  1. XR_004935468.1 RNA Sequence

  2. XR_870532.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080817.1: Suppressed sequence

    Description
    NM_001080817.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.