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Defa22 defensin, alpha, 22 [ Mus musculus (house mouse) ]

Gene ID: 382059, updated on 16-Oct-2021

Summary

Official Symbol
Defa22provided by MGI
Official Full Name
defensin, alpha, 22provided by MGI
Primary source
MGI:MGI:3639039
See related
Ensembl:ENSMUSG00000074443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Defcr22
Expression
Restricted expression toward large intestine adult (RPKM 2546.8) See more
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Genomic context

See Defa22 in Genome Data Viewer
Location:
8; 8 A2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (21652293..21653265)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (21162277..21163249)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (22301956..22302928)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger, MYM-type 5 pseudogene Neighboring gene defensin, alpha, 30 Neighboring gene predicted gene, 26240 Neighboring gene defensin, alpha, 31

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within defense response IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response in mucosa IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in membrane disruption in other organism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-defensin 22
Names
defensin-related cryptdin-22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207658.4NP_997541.2  alpha-defensin 22 precursor

    See identical proteins and their annotated locations for NP_997541.2

    Status: VALIDATED

    Source sequence(s)
    AC166039, AK008589, AV067993
    Consensus CDS
    CCDS40267.1
    UniProtKB/Swiss-Prot
    Q8C1N8
    UniProtKB/TrEMBL
    W4VSN6
    Related
    ENSMUSP00000096496.2, ENSMUST00000098897.2
    Conserved Domains (2) summary
    pfam00711
    Location:6690
    Defensin_beta; Beta defensin
    pfam00879
    Location:1451
    Defensin_propep; Defensin propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    21652293..21653265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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