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Crtc1 CREB regulated transcription coactivator 1 [ Mus musculus (house mouse) ]

Gene ID: 382056, updated on 18-Sep-2024

Summary

Official Symbol
Crtc1provided by MGI
Official Full Name
CREB regulated transcription coactivator 1provided by MGI
Primary source
MGI:MGI:2142523
See related
Ensembl:ENSMUSG00000003575 AllianceGenome:MGI:2142523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mect1; TORC1; TORC-1; mKIAA0616
Summary
Predicted to enable cAMP response element binding protein binding activity. Involved in entrainment of circadian clock by photoperiod and positive regulation of CREB transcription factor activity. Acts upstream of or within several processes, including energy homeostasis; memory; and negative regulation of membrane hyperpolarization. Located in cytoplasm and nucleus. Is expressed in limb and limb mesenchyme. Used to study major depressive disorder. Orthologous to human CRTC1 (CREB regulated transcription coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 24.8), cortex adult (RPKM 22.6) and 27 other tissues See more
Orthologs
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Genomic context

See Crtc1 in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70835002..70892720, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70382352..70439702, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene UPF1 RNA helicase and ATPase Neighboring gene STARR-seq mESC enhancer starr_21770 Neighboring gene predicted gene, 51533 Neighboring gene cartilage oligomeric matrix protein Neighboring gene kelch-like 26 Neighboring gene STARR-positive B cell enhancer ABC_E1368 Neighboring gene transmembrane protein 59-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1)  1 citation
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC90786

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP response element binding protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cAMP response element binding protein binding ISO
Inferred from Sequence Orthology
more info
 
enables cAMP response element binding protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cellular response to cAMP IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of membrane hyperpolarization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of CREB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in postsynapse to nucleus signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization IEA
Inferred from Electronic Annotation
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CREB-regulated transcription coactivator 1
Names
mucoepidermoid carcinoma translocated 1
mucoepidermoid carcinoma translocated protein 1 homolog
transducer of CREB protein 1
transducer of regulated cAMP response element-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004062.3NP_001004062.1  CREB-regulated transcription coactivator 1 isoform 2

    See identical proteins and their annotated locations for NP_001004062.1

    Status: VALIDATED

    Source sequence(s)
    AC158553
    Consensus CDS
    CCDS40372.1
    UniProtKB/Swiss-Prot
    Q68ED7, Q6ZQ85
    Related
    ENSMUSP00000075916.6, ENSMUST00000076615.6
    Conserved Domains (3) summary
    pfam12884
    Location:666
    TORC_N; Transducer of regulated CREB activity, N terminus
    pfam12885
    Location:148289
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:555630
    TORC_C; Transducer of regulated CREB activity, C terminus
  2. NM_001404415.1NP_001391344.1  CREB-regulated transcription coactivator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158553
  3. NM_001404416.1NP_001391345.1  CREB-regulated transcription coactivator 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158553
  4. NM_001404417.1NP_001391346.1  CREB-regulated transcription coactivator 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158553
  5. NM_001404418.1NP_001391347.1  CREB-regulated transcription coactivator 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC158553
  6. NM_001404419.1NP_001391348.1  CREB-regulated transcription coactivator 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC158553
  7. NM_001404420.1NP_001391349.1  CREB-regulated transcription coactivator 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC158553
  8. NM_001404421.1NP_001391350.1  CREB-regulated transcription coactivator 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC158553
  9. NM_001404422.1NP_001391351.1  CREB-regulated transcription coactivator 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC158553
  10. NM_001404423.1NP_001391352.1  CREB-regulated transcription coactivator 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC158553
  11. NM_001404424.1NP_001391353.1  CREB-regulated transcription coactivator 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC158553
  12. NM_001404425.1NP_001391354.1  CREB-regulated transcription coactivator 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC158553
  13. NM_001404426.1NP_001391355.1  CREB-regulated transcription coactivator 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC158553
  14. NM_001404427.1NP_001391356.1  CREB-regulated transcription coactivator 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC158553
  15. NM_001404428.1NP_001391357.1  CREB-regulated transcription coactivator 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC158553
  16. NM_001404429.1NP_001391358.1  CREB-regulated transcription coactivator 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC158553
  17. NM_001404430.1NP_001391359.1  CREB-regulated transcription coactivator 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC158553

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70835002..70892720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242309.4XP_011240611.1  CREB-regulated transcription coactivator 1 isoform X2

    Conserved Domains (3) summary
    pfam12884
    Location:666
    TORC_N; Transducer of regulated CREB activity, N-terminus
    pfam12885
    Location:148316
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:553628
    TORC_C; Transducer of regulated CREB activity, C-terminus
  2. XM_011242312.3XP_011240614.1  CREB-regulated transcription coactivator 1 isoform X6

    Conserved Domains (2) summary
    pfam12885
    Location:23161
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:427502
    TORC_C; Transducer of regulated CREB activity, C-terminus
  3. XM_036154147.1XP_036010040.1  CREB-regulated transcription coactivator 1 isoform X6

    Conserved Domains (2) summary
    pfam12885
    Location:23161
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:427502
    TORC_C; Transducer of regulated CREB activity, C-terminus
  4. XM_011242313.4XP_011240615.1  CREB-regulated transcription coactivator 1 isoform X7

    Conserved Domains (2) summary
    pfam12885
    Location:1157
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:423498
    TORC_C; Transducer of regulated CREB activity, C-terminus
  5. XM_011242314.4XP_011240616.1  CREB-regulated transcription coactivator 1 isoform X12

    Conserved Domains (2) summary
    pfam12884
    Location:666
    TORC_N; Transducer of regulated CREB activity, N-terminus
    pfam12885
    Location:148316
    TORC_M; Transducer of regulated CREB activity middle domain