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Ano8 anoctamin 8 [ Mus musculus (house mouse) ]

Gene ID: 382014, updated on 30-Apr-2024

Summary

Official Symbol
Ano8provided by MGI
Official Full Name
anoctamin 8provided by MGI
Primary source
MGI:MGI:2687327
See related
Ensembl:ENSMUSG00000034863 AllianceGenome:MGI:2687327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem16h
Summary
Predicted to be involved in chloride transport and transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; head mesenchyme; sensory organ; and viscerocranium. Orthologous to human ANO8 (anoctamin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 36.0), CNS E14 (RPKM 35.1) and 22 other tissues See more
Orthologs
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Genomic context

See Ano8 in Genome Data Viewer
Location:
8 B3.3; 8 34.43 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71928660..71938735, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71476016..71486092, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E6651 Neighboring gene STARR-positive B cell enhancer ABC_E358 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene DET1 and DDB1 associated 1 Neighboring gene STARR-positive B cell enhancer ABC_E2868 Neighboring gene GTP binding protein 3 Neighboring gene plasmalemma vesicle associated protein Neighboring gene coiled-coil domain containing 194 Neighboring gene 14-3-3 protein sigma-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT enables intracellularly calcium-gated chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables phospholipid scramblase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
anoctamin-8
Names
transmembrane protein 16H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164679.1NP_001158151.1  anoctamin-8

    See identical proteins and their annotated locations for NP_001158151.1

    Status: VALIDATED

    Source sequence(s)
    BC059855, BU708306, CD355145, CK624319, CX201380
    Consensus CDS
    CCDS52585.1
    UniProtKB/Swiss-Prot
    Q05CB5, Q69ZE4, Q6PB70
    UniProtKB/TrEMBL
    A0A1L1SR96
    Related
    ENSMUSP00000091157.5, ENSMUST00000093450.6
    Conserved Domains (1) summary
    pfam04547
    Location:237475
    Anoctamin; Calcium-activated chloride channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71928660..71938735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243645.2XP_030099505.1  anoctamin-8 isoform X8

    UniProtKB/TrEMBL
    A0A1L1SR96
    Conserved Domains (2) summary
    pfam04547
    Location:198456
    Anoctamin; Calcium-activated chloride channel
    pfam04625
    Location:8831012
    DEC-1_N; DEC-1 protein, N-terminal region
  2. XM_017312871.2XP_017168360.1  anoctamin-8 isoform X1

    UniProtKB/TrEMBL
    A0A1L1SR96
    Conserved Domains (2) summary
    PRK12323
    Location:10311210
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam04547
    Location:237606
    Anoctamin; Calcium-activated chloride channel
  3. XM_030243644.2XP_030099504.1  anoctamin-8 isoform X7

    UniProtKB/TrEMBL
    A0A1L1SR96
    Conserved Domains (2) summary
    PRK12323
    Location:8811060
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam04547
    Location:198456
    Anoctamin; Calcium-activated chloride channel
  4. XM_017312872.3XP_017168361.1  anoctamin-8 isoform X2

    UniProtKB/TrEMBL
    A0A1L1SR96
    Conserved Domains (2) summary
    PRK12323
    Location:9921171
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam04547
    Location:198567
    Anoctamin; Calcium-activated chloride channel
  5. XM_006509688.3XP_006509751.1  anoctamin-8 isoform X5

    UniProtKB/TrEMBL
    A0A1L1SR96
    Conserved Domains (2) summary
    PRK12323
    Location:9201099
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam04547
    Location:237495
    Anoctamin; Calcium-activated chloride channel
  6. XM_006509686.3XP_006509749.1  anoctamin-8 isoform X4

    UniProtKB/TrEMBL
    A0A1L1SR96
    Related
    ENSMUSP00000149365.2, ENSMUST00000213382.2
    Conserved Domains (2) summary
    PRK12323
    Location:9641143
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam04547
    Location:237539
    Anoctamin; Calcium-activated chloride channel
  7. XM_017312873.3XP_017168362.1  anoctamin-8 isoform X3

    UniProtKB/TrEMBL
    A0A1L1SR96
    Conserved Domains (2) summary
    PRK12323
    Location:9781157
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam04547
    Location:184553
    Anoctamin; Calcium-activated chloride channel
  8. XM_006509690.3XP_006509753.1  anoctamin-8 isoform X6

    UniProtKB/TrEMBL
    A0A1L1SR96
    Conserved Domains (2) summary
    PRK12323
    Location:8951074
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam04547
    Location:237470
    Anoctamin; Calcium-activated chloride channel