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KLRB1 killer cell lectin like receptor B1 [ Homo sapiens (human) ]

Gene ID: 3820, updated on 22-Sep-2022

Summary

Official Symbol
KLRB1provided by HGNC
Official Full Name
killer cell lectin like receptor B1provided by HGNC
Primary source
HGNC:HGNC:6373
See related
Ensembl:ENSG00000111796 MIM:602890; AllianceGenome:HGNC:6373
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKR; CD161; CLEC5B; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A
Summary
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 31.5), spleen (RPKM 28.1) and 14 other tissues See more
Orthologs
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Genomic context

See KLRB1 in Genome Data Viewer
Location:
12p13.31
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (9594551..9607916, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (9480754..9494170, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (9747147..9760512, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902873 Neighboring gene DEAD/H-box helicase 12, pseudogene Neighboring gene alpha-2-macroglobulin like 1 pseudogene Neighboring gene RAN binding protein 6 pseudogene Neighboring gene C-type lectin domain family 2 member D pseudogene Neighboring gene RNA, U6 small nuclear 700, pseudogene Neighboring gene GOT2 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138614

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of natural killer cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
killer cell lectin-like receptor subfamily B member 1
Names
C-type lectin domain family 5 member B
killer cell lectin-like receptor subfamily B, member 1
natural killer cell surface protein P1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002258.3NP_002249.1  killer cell lectin-like receptor subfamily B member 1

    See identical proteins and their annotated locations for NP_002249.1

    Status: REVIEWED

    Source sequence(s)
    AC006432, BF432813, U11276
    Consensus CDS
    CCDS8601.1
    UniProtKB/Swiss-Prot
    Q12918, Q24K24
    Related
    ENSP00000229402.3, ENST00000229402.4
    Conserved Domains (1) summary
    cd03593
    Location:94212
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    9594551..9607916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    9480754..9494170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)