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Itgad integrin, alpha D [ Mus musculus (house mouse) ]

Gene ID: 381924, updated on 23-Jun-2021

Summary

Official Symbol
Itgadprovided by MGI
Official Full Name
integrin, alpha Dprovided by MGI
Primary source
MGI:MGI:3578624
See related
Ensembl:ENSMUSG00000070369
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd11d
Expression
Biased expression in spleen adult (RPKM 20.4), testis adult (RPKM 5.2) and 1 other tissue See more
Orthologs
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Genomic context

See Itgad in Genome Data Viewer
Location:
7; 7 F3
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127773105..127822988)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (128173933..128205504)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (135317460..135349018)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene integrin alpha X Neighboring gene mitochondrial carrier triple repeat 1 pseudogene Neighboring gene predicted gene, 39091 Neighboring gene RIKEN cDNA 4931431B13 gene Neighboring gene cytochrome c oxidase subunit 6A2 Neighboring gene RIKEN cDNA 9130023H24 gene Neighboring gene armadillo repeat containing 5 Neighboring gene transforming growth factor beta 1 induced transcript 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029872.3NP_001025043.3  integrin alpha-D precursor

    See identical proteins and their annotated locations for NP_001025043.3

    Status: VALIDATED

    Source sequence(s)
    AC124566, AW495405
    Consensus CDS
    CCDS21890.2
    UniProtKB/TrEMBL
    E9PXZ7
    Related
    ENSMUSP00000033051.10, ENSMUST00000033051.16
    Conserved Domains (4) summary
    smart00191
    Location:559614
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:156367
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11651178
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6661003
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127773105..127822988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153200.1XP_036009093.1  integrin alpha-D isoform X1

    Conserved Domains (3) summary
    smart00191
    Location:559614
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:156367
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:6661068
    Integrin_alpha2; Integrin alpha
  2. XM_006507971.3XP_006508034.1  integrin alpha-D isoform X2

    Conserved Domains (4) summary
    smart00191
    Location:549604
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:156357
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11551168
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6561058
    Integrin_alpha2; Integrin alpha
  3. XM_006507972.3XP_006508035.1  integrin alpha-D isoform X3

    UniProtKB/TrEMBL
    H3BKX8
    Related
    ENSMUSP00000135572.2, ENSMUST00000177111.8
    Conserved Domains (4) summary
    smart00191
    Location:523578
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:156331
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11291142
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6301032
    Integrin_alpha2; Integrin alpha

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177632.1: Suppressed sequence

    Description
    NM_001177632.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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