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Cracr2a calcium release activated channel regulator 2A [ Mus musculus (house mouse) ]

Gene ID: 381812, updated on 5-Mar-2024

Summary

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Official Symbol
Cracr2aprovided by MGI
Official Full Name
calcium release activated channel regulator 2Aprovided by MGI
Primary source
MGI:MGI:2685919
See related
Ensembl:ENSMUSG00000061414 AllianceGenome:MGI:2685919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm462; Gm1073; Efcab4b
Summary
Predicted to enable GTPase activity and calcium ion binding activity. Involved in T-helper 1 cell differentiation and positive regulation of JNK cascade. Predicted to be located in Golgi membrane; plasma membrane; and vesicle. Predicted to be active in several cellular components, including Weibel-Palade body; immunological synapse; and trans-Golgi network membrane. Is expressed in several structures, including alimentary system; bladder; cerebellum; male reproductive gland or organ; and trigeminal nerve. Orthologous to human CRACR2A (calcium release activated channel regulator 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 2.8), lung adult (RPKM 2.7) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 F3; 6 62.39 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (127538299..127651197)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (127561062..127674234)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17414 Neighboring gene predicted gene, 34091 Neighboring gene STARR-positive B cell enhancer ABC_E8132 Neighboring gene STARR-positive B cell enhancer ABC_E3683 Neighboring gene predicted gene, 34148 Neighboring gene poly (ADP-ribose) polymerase family, member 11 Neighboring gene STARR-seq mESC enhancer starr_17416 Neighboring gene STARR-positive B cell enhancer ABC_E2210 Neighboring gene STARR-positive B cell enhancer ABC_E9677 Neighboring gene protein arginine N-methyltransferase 8 Neighboring gene predicted gene, 38900 Neighboring gene RIKEN cDNA 4921513H07 gene Neighboring gene STARR-seq mESC enhancer starr_17419

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. Woo JS, et al. J Immunol, 2018 Aug 15. PMID 29987160, Free PMC Article
  2. A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals. Srikanth S, et al. Sci Signal, 2016 Mar 22. PMID 27016526, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study demonstrates the requirement of CRACR2A-mediated TCR signaling in Th1 responses as well as pathogenic conversion of Th17 cells, which occurs at the site of inflammation
    Title: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.
  2. GTP binding and prenylation of CRACR2A were associated with its localization near the Golgi and its stability
    Title: A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in T-helper 1 cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in T-helper 1 cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in response to histamine ISO
Inferred from Sequence Orthology
more info
  
involved_in store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Weibel-Palade body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
EF-hand calcium-binding domain-containing protein 4B
Names
EF-hand calcium binding domain 4B
ras-related protein Rab-46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033464.4 → NP_001028636.1  EF-hand calcium-binding domain-containing protein 4B isoform 2

    See identical proteins and their annotated locations for NP_001028636.1

    Status: VALIDATED

    Source sequence(s)
    AC173480
    Consensus CDS
    CCDS20566.1
    UniProtKB/Swiss-Prot
    Q3UP38
    Related
    ENSMUSP00000071494.5, ENSMUST00000071563.5
    Conserved Domains (1) summary
    pfam13499
    Location:49 → 103
    EF-hand_7; EF-hand domain pair

  2. NM_001368877.1 → NP_001355806.1  EF-hand calcium-binding domain-containing protein 4B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC127373, AC173480
    Consensus CDS
    CCDS90125.1
    UniProtKB/Swiss-Prot
    A0A1D5RLZ8, B9EKF2, Q3UP38
    Related
    ENSMUSP00000148569.2, ENSMUST00000212051.2
    Conserved Domains (3) summary
    PRK12309
    Location:7 → 107
    PRK12309; transaldolase
    cd00154
    Location:541 → 699
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    COG1196
    Location:117 → 403
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    127538299..127651197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506341.5 → XP_006506404.1  EF-hand calcium-binding domain-containing protein 4B isoform X1

    See identical proteins and their annotated locations for XP_006506404.1

    Conserved Domains (3) summary
    PRK12309
    Location:32 → 132
    PRK12309; transaldolase
    cd00154
    Location:566 → 724
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    COG1196
    Location:142 → 428
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_006506343.5 → XP_006506406.1  EF-hand calcium-binding domain-containing protein 4B isoform X2

    Conserved Domains (3) summary
    PRK12309
    Location:20 → 120
    PRK12309; transaldolase
    cd00154
    Location:554 → 712
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    COG1196
    Location:130 → 416
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_006506351.5 → XP_006506414.1  EF-hand calcium-binding domain-containing protein 4B isoform X5

    See identical proteins and their annotated locations for XP_006506414.1

    Conserved Domains (3) summary
    PRK12309
    Location:32 → 132
    PRK12309; transaldolase
    COG4372
    Location:135 → 355
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    PRK12704
    Location:228 → 305
    PRK12704; phosphodiesterase; Provisional

  4. XM_036166263.1 → XP_036022156.1  EF-hand calcium-binding domain-containing protein 4B isoform X5

    Conserved Domains (3) summary
    PRK12309
    Location:32 → 132
    PRK12309; transaldolase
    COG4372
    Location:135 → 355
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    PRK12704
    Location:228 → 305
    PRK12704; phosphodiesterase; Provisional

  5. XM_006506345.5 → XP_006506408.1  EF-hand calcium-binding domain-containing protein 4B isoform X3

    Conserved Domains (3) summary
    PRK12309
    Location:32 → 132
    PRK12309; transaldolase
    cd00154
    Location:566 → 664
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    COG1196
    Location:142 → 428
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. XM_006506346.5 → XP_006506409.1  EF-hand calcium-binding domain-containing protein 4B isoform X4

    Conserved Domains (3) summary
    PRK12309
    Location:32 → 132
    PRK12309; transaldolase
    cd00154
    Location:566 → 670
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    COG1196
    Location:142 → 428
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_011241400.4 → XP_011239702.1  EF-hand calcium-binding domain-containing protein 4B isoform X1

    See identical proteins and their annotated locations for XP_011239702.1

    Conserved Domains (3) summary
    PRK12309
    Location:32 → 132
    PRK12309; transaldolase
    cd00154
    Location:566 → 724
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    COG1196
    Location:142 → 428
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_001785146.3 RNA Sequence

  2. XR_001785147.3 RNA Sequence

  3. XR_377479.5 RNA Sequence

  4. XR_377478.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UP38.2 GenPept UniProtKB/Swiss-Prot:Q3UP38

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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