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Wee2 WEE1 homolog 2 (S. pombe) [ Mus musculus (house mouse) ]

Gene ID: 381759, updated on 5-Jan-2023

Summary

Official Symbol
Wee2provided by MGI
Official Full Name
WEE1 homolog 2 (S. pombe)provided by MGI
Primary source
MGI:MGI:3027899
See related
Ensembl:ENSMUSG00000037159 AllianceGenome:MGI:3027899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wee1B; Gm1065
Summary
Predicted to enable protein tyrosine kinase activity. Involved in several processes, including female pronucleus assembly; negative regulation of oocyte maturation; and regulation of phosphorylation. Located in cytoplasm and nucleus. Is expressed in 1-cell stage embryo; olfactory epithelium; and ovary. Orthologous to human WEE2 (WEE2 oocyte meiosis inhibiting kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Wee2 in Genome Data Viewer
Location:
6; 6 B1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (40412180..40443749)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (40435246..40466815)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 178B Neighboring gene acylglycerol kinase Neighboring gene DENN domain containing 11 Neighboring gene taste receptor, type 2, member 137 Neighboring gene single-stranded DNA binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

Markers

Homology

Clone Names

  • MGC60753

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
wee1-like protein kinase 2
Names
mWee1B
wee1-like protein kinase 1B
wee1B kinase
NP_958758.2
XP_006506389.1
XP_006506390.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201370.2NP_958758.2  wee1-like protein kinase 2

    See identical proteins and their annotated locations for NP_958758.2

    Status: VALIDATED

    Source sequence(s)
    AK139573, BY725757, CJ200934
    Consensus CDS
    CCDS20029.1
    UniProtKB/Swiss-Prot
    Q66JT0, Q7TPV9
    Related
    ENSMUSP00000038754.9, ENSMUST00000038907.9
    Conserved Domains (1) summary
    cl21453
    Location:207477
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    40412180..40443749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506326.4XP_006506389.1  wee1-like protein kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_006506389.1

    UniProtKB/Swiss-Prot
    Q66JT0, Q7TPV9
    Conserved Domains (1) summary
    cl21453
    Location:207477
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006506327.4XP_006506390.1  wee1-like protein kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:101371
    PKc_like; Protein Kinases, catalytic domain