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Drc1 dynein regulatory complex subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 381738, updated on 5-Mar-2024

Summary

Official Symbol
Drc1provided by MGI
Official Full Name
dynein regulatory complex subunit 1provided by MGI
Primary source
MGI:MGI:2685906
See related
Ensembl:ENSMUSG00000073102 AllianceGenome:MGI:2685906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1060; Ccdc164; b2b1654Clo
Summary
Acts upstream of or within determination of left/right symmetry and heart development. Is active in cytosol. Is expressed in brain; nasal cavity respiratory epithelium; and respiratory system epithelium. Used to study Kartagener syndrome; primary ciliary dyskinesia 21; and visceral heterotaxy. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 21. Orthologous to human DRC1 (dynein regulatory complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 10.4), cortex adult (RPKM 2.7) and 5 other tissues See more
Orthologs
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Genomic context

See Drc1 in Genome Data Viewer
Location:
5 B1; 5 16.42 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30486328..30524039)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30281335..30366695)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1678 Neighboring gene predicted gene, 54326 Neighboring gene selenoprotein I Neighboring gene predicted gene 16288 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:30645501-30645684 Neighboring gene otoferlin Neighboring gene STARR-seq mESC enhancer starr_12752 Neighboring gene ciliary microtubule inner protein 2C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in axonemal dynein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in axonemal dynein complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cilium-dependent cell motility IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cilium-dependent cell motility ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of axonemal dynein complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynein regulatory complex protein 1
Names
coiled-coil domain containing 164
coiled-coil domain-containing protein 164

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033460.4NP_001028632.1  dynein regulatory complex protein 1

    See identical proteins and their annotated locations for NP_001028632.1

    Status: VALIDATED

    Source sequence(s)
    AC241618, AC242405
    Consensus CDS
    CCDS84857.1
    UniProtKB/Swiss-Prot
    B9EKF0, Q3USS3
    Related
    ENSMUSP00000098992.4, ENSMUST00000101448.5
    Conserved Domains (2) summary
    pfam14772
    Location:100200
    NYD-SP28; Sperm tail
    pfam14775
    Location:673731
    NYD-SP28_assoc; Sperm tail C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    30486328..30524039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320953.3XP_017176442.1  dynein regulatory complex protein 1 isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:117372
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam14772
    Location:100200
    NYD-SP28; Sperm tail
    pfam14775
    Location:644699
    NYD-SP28_assoc; Sperm tail C-terminal domain
  2. XM_017320954.2XP_017176443.1  dynein regulatory complex protein 1 isoform X3

    Conserved Domains (1) summary
    pfam14775
    Location:467526
    NYD-SP28_assoc; Sperm tail C-terminal domain
  3. XM_036165255.1XP_036021148.1  dynein regulatory complex protein 1 isoform X3

    Conserved Domains (1) summary
    pfam14775
    Location:467526
    NYD-SP28_assoc; Sperm tail C-terminal domain
  4. XM_030254633.1XP_030110493.1  dynein regulatory complex protein 1 isoform X4

    Conserved Domains (2) summary
    pfam09787
    Location:3149
    Golgin_A5; Golgin subfamily A member 5
    pfam14775
    Location:438493
    NYD-SP28_assoc; Sperm tail C-terminal domain
  5. XM_036165253.1XP_036021146.1  dynein regulatory complex protein 1 isoform X2

    Conserved Domains (3) summary
    COG1196
    Location:13246
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam14772
    Location:145
    NYD-SP28; Sperm tail
    pfam14775
    Location:518577
    NYD-SP28_assoc; Sperm tail C-terminal domain
  6. XM_036165254.1XP_036021147.1  dynein regulatory complex protein 1 isoform X2

    Conserved Domains (3) summary
    COG1196
    Location:13246
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam14772
    Location:145
    NYD-SP28; Sperm tail
    pfam14775
    Location:518577
    NYD-SP28_assoc; Sperm tail C-terminal domain