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stet stem cell tumor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38169, updated on 8-Apr-2026
Official Symbol
stetprovided by FlyBase
Official Full Name
stem cell tumorprovided by FlyBase
Primary source
FLYBASE:FBgn0020248
Locus tag
Dmel_CG33166
See related
AllianceGenome:FB:FBgn0020248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
B-Rho; brho; Brho; CG12083; CG12504; CG33166; Dmel\CG33166; rho-2; Rho-2; rho2; Rho2; Stet
Summary
Enables serine-type endopeptidase activity. Involved in epidermal growth factor receptor ligand maturation and male germ-line stem cell population maintenance. Located in Golgi membrane. Orthologous to human RHBDL1 (rhomboid like 1) and RHBDL3 (rhomboid like 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See stet in Genome Data Viewer
Location:
62A2-62A2; 3-0.5 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1475438..1489547, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1475438..1489547, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Protein tyrosine phosphatase 61F Neighboring gene ncRNA Neighboring gene rhomboid Neighboring gene N(alpha)-acetyltransferase 30 B Neighboring gene small non-coding RNA:CR43701 Neighboring gene robl62A Neighboring gene antisense RNA:CR45812 Neighboring gene small Cajal body-specific RNA : MeU2-48 Neighboring gene uncharacterized protein Neighboring gene half pint

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Alternative splice variants of rhomboid proteins: Comparative analysis of database entries for select model organisms and validation of functional potential. Powles J, et al. F1000Res, 2018. PMID 32201561, Free PMC Article
  2. A temporal signature of epidermal growth factor signaling regulates the differentiation of germline cells in testes of Drosophila melanogaster. Hudson AG, et al. PLoS One, 2013. PMID 23940622, Free PMC Article
  3. Developmental roles of Rhomboid proteases. Shilo BZ. Semin Cell Dev Biol, 2016 Dec. PMID 27423914
  4. Control of germline stem cell division frequency--a novel, developmentally regulated role for epidermal growth factor signaling. Parrott BB, et al. PLoS One, 2012. PMID 22586473, Free PMC Article
  5. Polarity in stem cell division: asymmetric stem cell division in tissue homeostasis. Yamashita YM, et al. Cold Spring Harb Perspect Biol, 2010 Jan. PMID 20182603, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epidermal growth factor receptor ligand maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epidermal growth factor receptor ligand maturation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in male germ-line stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
stem cell tumor
Names
CG33166-PA
CG33166-PB
brother of rhomboid
rhomboid-2
rhomboid2
stet-PA
stet-PB
NP_788450.1
NP_788451.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1475438..1489547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176272.2 → NP_788450.1  stem cell tumor, isoform B

    See identical proteins and their annotated locations for NP_788450.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P37, Q9W0E9
    Related
    FBpp0072596
    Conserved Domains (3) summary
    pfam01694
    Location:262 → 428
    Rhomboid; Rhomboid family
    pfam13499
    Location:91 → 156
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:75 → 115
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_176273.2 → NP_788451.1  stem cell tumor, isoform A

    See identical proteins and their annotated locations for NP_788451.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W0F1
    Related
    FBpp0072597
    Conserved Domains (1) summary
    pfam01694
    Location:107 → 273
    Rhomboid; Rhomboid family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86P37 Q86P37
Q9BML4 Q9BML4
Q9W0E9 Q9W0E9
Q9W0F1 Q9W0F1

Gene LinkOut

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