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Tbc1d2 TBC1 domain family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 381605, updated on 4-May-2024

Summary

Official Symbol
Tbc1d2provided by MGI
Official Full Name
TBC1 domain family, member 2provided by MGI
Primary source
MGI:MGI:2652885
See related
Ensembl:ENSMUSG00000039813 AllianceGenome:MGI:2652885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1037; PARIS1; PARIS-1; A630005A06Rik
Summary
Predicted to enable GTPase activator activity and cadherin binding activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in several cellular components, including cytoplasmic vesicle; cytosol; and nucleoplasm. Orthologous to human TBC1D2 (TBC1 domain family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 17.6), bladder adult (RPKM 7.1) and 14 other tissues See more
Orthologs
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Genomic context

See Tbc1d2 in Genome Data Viewer
Location:
4 B1; 4 25.04 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46604390..46650396, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46604390..46650340, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 14 Neighboring gene STARR-positive B cell enhancer ABC_E4623 Neighboring gene predicted gene, 16731 Neighboring gene coronin, actin binding protein 2A Neighboring gene STARR-positive B cell enhancer ABC_E3489 Neighboring gene STARR-positive B cell enhancer ABC_E3490 Neighboring gene STARR-positive B cell enhancer ABC_E6173 Neighboring gene STARR-positive B cell enhancer ABC_E2111 Neighboring gene predicted gene, 54221 Neighboring gene predicted gene, 54222 Neighboring gene predicted gene, 31850 Neighboring gene predicted gene, 42281 Neighboring gene STARR-seq mESC enhancer starr_10135 Neighboring gene gamma-aminobutyric acid type B receptor subunit 2 Neighboring gene predicted gene, 32208 Neighboring gene predicted gene, 32135

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TBC1 domain family member 2A
Names
likely ortholog of H. sapiens TBC1 domain family, member 2 (TBC1D2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198664.3NP_941066.3  TBC1 domain family member 2A

    See identical proteins and their annotated locations for NP_941066.3

    Status: VALIDATED

    Source sequence(s)
    AL683884, BX571848, BX682536
    Consensus CDS
    CCDS18155.1
    UniProtKB/Swiss-Prot
    B1AVH7, Q3UFW9, Q8BYB1
    Related
    ENSMUSP00000081670.6, ENSMUST00000084621.12
    Conserved Domains (3) summary
    smart00164
    Location:619831
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01265
    Location:45146
    PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain
    pfam00169
    Location:45138
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    46604390..46650396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538047.5XP_006538110.1  TBC1 domain family member 2A isoform X2

    Conserved Domains (4) summary
    smart00164
    Location:620832
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG4913
    Location:300565
    COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
    PRK14951
    Location:192404
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd01265
    Location:45146
    PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain
  2. XM_006538046.5XP_006538109.1  TBC1 domain family member 2A isoform X1

    Conserved Domains (4) summary
    smart00164
    Location:620832
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG4913
    Location:300565
    COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
    PRK14951
    Location:192404
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd01265
    Location:45146
    PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain
  3. XM_036164218.1XP_036020111.1  TBC1 domain family member 2A isoform X3

    Conserved Domains (2) summary
    smart00164
    Location:399611
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG4913
    Location:79319
    COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
  4. XM_030253640.1XP_030109500.1  TBC1 domain family member 2A isoform X4

    Conserved Domains (1) summary
    smart00164
    Location:163375
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  5. XM_006538050.2XP_006538113.1  TBC1 domain family member 2A isoform X5

    Conserved Domains (3) summary
    smart00164
    Location:475687
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG4913
    Location:155395
    COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
    pfam15730
    Location:84151
    DUF4680; Domain of unknown function (DUF4680)
  6. XM_006538049.1XP_006538112.1  TBC1 domain family member 2A isoform X4

    Conserved Domains (1) summary
    smart00164
    Location:163375
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs