U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tbc1d2 TBC1 domain family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 381605, updated on 26-Sep-2022

Summary

Go to the top of the page Help
Official Symbol
Tbc1d2provided by MGI
Official Full Name
TBC1 domain family, member 2provided by MGI
Primary source
MGI:MGI:2652885
See related
Ensembl:ENSMUSG00000039813 AllianceGenome:MGI:2652885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1037; PARIS1; PARIS-1; A630005A06Rik
Summary
Predicted to enable GTPase activator activity and cadherin binding activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in several cellular components, including cytoplasmic vesicle; cytosol; and nucleoplasm. Orthologous to human TBC1D2 (TBC1 domain family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 17.6), bladder adult (RPKM 7.1) and 14 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tbc1d2 in Genome Data Viewer
Location:
4; 4 B1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46604390..46650396, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46604390..46650340, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 14 Neighboring gene predicted gene, 16731 Neighboring gene coronin, actin binding protein 2A Neighboring gene predicted gene, 54221 Neighboring gene predicted gene, 54222 Neighboring gene predicted gene, 31850 Neighboring gene predicted gene, 42281 Neighboring gene gamma-aminobutyric acid (GABA) B receptor, 2 Neighboring gene predicted gene, 32208 Neighboring gene predicted gene, 32135

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus. Jaber N, et al. J Cell Sci, 2016 Dec 1. PMID 27793976, Free PMC Article
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Vps34 has a previously unknown role in regulating Rab7 activity and late endosomal trafficking.
    Title: Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
TBC1 domain family member 2A
Names
likely ortholog of H. sapiens TBC1 domain family, member 2 (TBC1D2)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198664.3 → NP_941066.3  TBC1 domain family member 2A

    See identical proteins and their annotated locations for NP_941066.3

    Status: VALIDATED

    Source sequence(s)
    AL683884, BX571848, BX682536
    Consensus CDS
    CCDS18155.1
    UniProtKB/Swiss-Prot
    B1AVH7, Q8BYB1
    Related
    ENSMUSP00000081670.6, ENSMUST00000084621.12
    Conserved Domains (3) summary
    smart00164
    Location:619 → 831
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01265
    Location:45 → 146
    PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain
    pfam00169
    Location:45 → 138
    PH; PH domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    46604390..46650396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538047.5 → XP_006538110.1  TBC1 domain family member 2A isoform X2

    Conserved Domains (4) summary
    smart00164
    Location:620 → 832
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG4913
    Location:300 → 565
    COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
    PRK14951
    Location:192 → 404
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd01265
    Location:45 → 146
    PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain

  2. XM_006538046.5 → XP_006538109.1  TBC1 domain family member 2A isoform X1

    Conserved Domains (4) summary
    smart00164
    Location:620 → 832
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG4913
    Location:300 → 565
    COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
    PRK14951
    Location:192 → 404
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd01265
    Location:45 → 146
    PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain

  3. XM_036164218.1 → XP_036020111.1  TBC1 domain family member 2A isoform X3

    Conserved Domains (2) summary
    smart00164
    Location:399 → 611
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG4913
    Location:79 → 319
    COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]

  4. XM_030253640.1 → XP_030109500.1  TBC1 domain family member 2A isoform X4

    Conserved Domains (1) summary
    smart00164
    Location:163 → 375
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  5. XM_006538050.2 → XP_006538113.1  TBC1 domain family member 2A isoform X5

    Conserved Domains (3) summary
    smart00164
    Location:475 → 687
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG4913
    Location:155 → 395
    COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
    pfam15730
    Location:84 → 151
    DUF4680; Domain of unknown function (DUF4680)

  6. XM_006538049.1 → XP_006538112.1  TBC1 domain family member 2A isoform X4

    Conserved Domains (1) summary
    smart00164
    Location:163 → 375
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AVH7.1 GenPept UniProtKB/Swiss-Prot:B1AVH7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous