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KLK1 kallikrein 1 [ Homo sapiens (human) ]

Gene ID: 3816, updated on 7-Dec-2018

Summary

Official Symbol
KLK1provided by HGNC
Official Full Name
kallikrein 1provided by HGNC
Primary source
HGNC:HGNC:6357
See related
Ensembl:ENSG00000167748 MIM:147910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hK1; KLKR; Klk6
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]
Expression
Biased expression in salivary gland (RPKM 569.2) and pancreas (RPKM 508.7) See more
Orthologs

Genomic context

See KLK1 in Genome Data Viewer
Location:
19q13.33
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (50819146..50823787, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51322402..51327043, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene chromosome 19 open reading frame 48 Neighboring gene small nucleolar RNA, C/D box 88C Neighboring gene long intergenic non-protein coding RNA 1869 Neighboring gene uncharacterized LOC105372441 Neighboring gene kallikrein related peptidase 15 Neighboring gene KLK3 upstream enhancer/promoter region Neighboring gene kallikrein related peptidase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kallikrein-1
Names
glandular kallikrein 1
kallikrein 1, renal/pancreas/salivary
kallikrein serine protease 1
kidney/pancreas/salivary gland kallikrein
tissue kallikrein
NP_002248.1
XP_011525244.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012094.1 RefSeqGene

    Range
    5001..9642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002257.4NP_002248.1  kallikrein-1 preproprotein

    See identical proteins and their annotated locations for NP_002248.1

    Status: REVIEWED

    Source sequence(s)
    BP323011, CA772631, X13561
    Consensus CDS
    CCDS12804.1
    UniProtKB/Swiss-Prot
    P06870
    UniProtKB/TrEMBL
    A0A1R3UCD2
    Related
    ENSP00000301420.1, ENST00000301420.2
    Conserved Domains (1) summary
    cd00190
    Location:25257
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    50819146..50823787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526942.1XP_011525244.1  kallikrein-1 isoform X1

    UniProtKB/TrEMBL
    A0A1L2BPJ2
    Conserved Domains (1) summary
    smart00020
    Location:13152
    Tryp_SPc; Trypsin-like serine protease
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