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Xkr8 X-linked Kx blood group related 8 [ Mus musculus (house mouse) ]

Gene ID: 381560, updated on 9-May-2024

Summary

Official Symbol
Xkr8provided by MGI
Official Full Name
X-linked Kx blood group related 8provided by MGI
Primary source
MGI:MGI:2685877
See related
Ensembl:ENSMUSG00000037752 AllianceGenome:MGI:2685877
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
XRG8; mXkr8; Gm1031; 4931440N07Rik
Summary
Enables phospholipid scramblase activity. Involved in engulfment of apoptotic cell; neutrophil clearance; and phosphatidylserine exposure on apoptotic cell surface. Acts upstream of or within establishment of localization in cell; positive regulation of myoblast differentiation; and tolerance induction to self antigen. Is active in plasma membrane. Orthologous to human XKR8 (XK related 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 36.0), ovary adult (RPKM 3.3) and 7 other tissues See more
Orthologs
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Genomic context

Location:
4 D2.3; 4 65.81 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132452212..132459916, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132724901..132732614, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10263 Neighboring gene platelet-activating factor receptor Neighboring gene STARR-seq mESC enhancer starr_11574 Neighboring gene STARR-seq mESC enhancer starr_11575 Neighboring gene STARR-seq mESC enhancer starr_11576 Neighboring gene EYA transcriptional coactivator and phosphatase 3 Neighboring gene STARR-positive B cell enhancer ABC_E9241 Neighboring gene sphingomyelin phosphodiesterase, acid-like 3B Neighboring gene STARR-positive B cell enhancer ABC_E426 Neighboring gene replication protein A2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

General gene information

Markers

Clone Names

  • MGC67219

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phospholipid scramblase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipid scramblase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process involved in development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in engulfment of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in engulfment of apoptotic cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylserine exposure on apoptotic cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylserine exposure on apoptotic cell surface IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphatidylserine exposure on apoptotic cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylserine exposure on apoptotic cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylserine exposure on apoptotic cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tolerance induction to self antigen IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
XK-related protein 8
Names
X Kell blood group precursor related family member 8 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201368.1NP_958756.1  XK-related protein 8

    See identical proteins and their annotated locations for NP_958756.1

    Status: PROVISIONAL

    Source sequence(s)
    AK029920
    Consensus CDS
    CCDS18732.1
    UniProtKB/Swiss-Prot
    Q8C0T0
    Related
    ENSMUSP00000041205.5, ENSMUST00000045550.5
    Conserved Domains (1) summary
    pfam09815
    Location:17345
    XK-related; XK-related protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132452212..132459916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538989.5XP_006539052.1  XK-related protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006539052.1

    Conserved Domains (1) summary
    pfam09815
    Location:11243
    XK-related; XK-related protein
  2. XM_006538988.5XP_006539051.1  XK-related protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006539051.1

    Conserved Domains (1) summary
    pfam09815
    Location:11243
    XK-related; XK-related protein