Mup20 major urinary protein 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mup20provided by MGI
Official Full Name: major urinary protein 20provided by MGI
Primary source: MGI:MGI:3651981
See related: Ensembl:ENSMUSG00000078672 AllianceGenome:MGI:3651981
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mup24; darcin; Gm12560
Summary: Enables mating pheromone activity and pheromone binding activity. Involved in several processes, including olfactory learning; positive regulation of neural precursor cell proliferation; and vocalization behavior. Located in extracellular region. Is expressed in liver. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Restricted expression toward liver adult (RPKM 7.8) See more
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Genomic context

Location:: 4 B3; 4 32.98 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (61929604..61972380, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (62011337..62054143, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

14 critical amino acids in the binding pocket involved in ligand interactions were identified in MUP20 using in silico techniques and 7 MUP20 mutants were synthesized and characterized to produce a set of proteins with diverse ligand binding profiles
Title: Effects of point mutations in the binding pocket of the mouse major urinary protein MUP20 on ligand affinity and specificity.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mating pheromone activity	IDA Inferred from Direct Assay more info	PubMed
enables odorant binding	IBA Inferred from Biological aspect of Ancestor more info
enables odorant binding	ISO Inferred from Sequence Orthology more info
enables pheromone activity	IEA Inferred from Electronic Annotation more info
enables pheromone binding	IDA Inferred from Direct Assay more info	PubMed
enables pheromone binding	IEA Inferred from Electronic Annotation more info
enables small molecule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within olfactory learning	IDA Inferred from Direct Assay more info	PubMed
involved_in olfactory learning	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neural precursor cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neurogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vocalization behavior	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: major urinary protein 20

Names: major urinary protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012323.1 → NP_001012323.1 major urinary protein 20 precursor

See identical proteins and their annotated locations for NP_001012323.1

Status: VALIDATED

Source sequence(s)

BC089613

Consensus CDS

CCDS18233.1

UniProtKB/Swiss-Prot

Q5FW60

Related

ENSMUSP00000073667.4, ENSMUST00000074018.4

Conserved Domains (1) summary

cd19428
Location:24 → 181

lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

61929604..61972380 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538045.4 → XP_006538108.1 major urinary protein 20 isoform X1

See identical proteins and their annotated locations for XP_006538108.1

UniProtKB/Swiss-Prot

Q5FW60

Conserved Domains (1) summary

cd19428
Location:24 → 181

lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins