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Rxfp1 relaxin/insulin-like family peptide receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 381489, updated on 14-May-2024

Summary

Official Symbol
Rxfp1provided by MGI
Official Full Name
relaxin/insulin-like family peptide receptor 1provided by MGI
Primary source
MGI:MGI:2682211
See related
Ensembl:ENSMUSG00000034009 AllianceGenome:MGI:2682211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lgr7; Gm1018
Summary
Enables hormone binding activity. Acts upstream of or within several processes, including lung connective tissue development; nipple morphogenesis; and parturition. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in brain and metanephros. Orthologous to human RXFP1 (relaxin family peptide receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 9.6), cortex adult (RPKM 2.8) and 4 other tissues See more
Orthologs
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Genomic context

See Rxfp1 in Genome Data Viewer
Location:
3 E3; 3 34.94 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (79548910..79645258, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (79641600..79737951, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930579G24 gene Neighboring gene peptidylprolyl isomerase D (cyclophilin D) Neighboring gene electron transferring flavoprotein, dehydrogenase Neighboring gene STARR-seq mESC enhancer starr_08007 Neighboring gene VISTA enhancer mm1650 Neighboring gene STARR-seq mESC enhancer starr_08009 Neighboring gene transmembrane protein 144 Neighboring gene STARR-positive B cell enhancer ABC_E3438 Neighboring gene predicted gene, 26420 Neighboring gene STARR-seq mESC enhancer starr_08010 Neighboring gene STARR-seq mESC enhancer starr_08011 Neighboring gene STARR-seq mESC enhancer starr_08012 Neighboring gene golgi associated kinase 1B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lung connective tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myofibroblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nipple morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within parturition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
relaxin receptor 1
Names
leucine-rich repeat-containing 7
leucine-rich repeat-containing G-protein coupled receptor 7
relaxin family peptide receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212452.3NP_997617.1  relaxin receptor 1 precursor

    See identical proteins and their annotated locations for NP_997617.1

    Status: VALIDATED

    Source sequence(s)
    AC122462, AC159281
    Consensus CDS
    CCDS17420.1
    UniProtKB/Swiss-Prot
    Q6R6I7, Q80UD3
    Related
    ENSMUSP00000077611.6, ENSMUST00000078527.13
    Conserved Domains (6) summary
    cd00112
    Location:2762
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00116
    Location:147331
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:110127
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:128151
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00001
    Location:422681
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam13855
    Location:151210
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    79548910..79645258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252661.2XP_030108521.1  relaxin receptor 1 isoform X2

    Conserved Domains (5) summary
    sd00033
    Location:222
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:2281
    LRR_8; Leucine rich repeat
    cd14964
    Location:279303
    7tm_GPCRs; TM helix 1 [structural motif]
    NF033189
    Location:2234
    internalin_A; class 1 internalin InlA
    cl28897
    Location:277563
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_006501629.3XP_006501692.1  relaxin receptor 1 isoform X1

    Conserved Domains (5) summary
    cd00112
    Location:2762
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    sd00033
    Location:128151
    LRR_RI; leucine-rich repeat [structural motif]
    cd15965
    Location:405691
    7tmA_RXFP1_LGR7; relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors
    pfam13855
    Location:151210
    LRR_8; Leucine rich repeat
    NF033189
    Location:126334
    internalin_A; class 1 internalin InlA
  3. XM_030252662.2XP_030108522.1  relaxin receptor 1 isoform X3

    Conserved Domains (5) summary
    COG4886
    Location:9145
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:2043
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:43102
    LRR_8; Leucine rich repeat
    cd14964
    Location:178204
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:177463
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily