Pabpc1l poly(A) binding protein, cytoplasmic 1-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pabpc1lprovided by MGI
Official Full Name: poly(A) binding protein, cytoplasmic 1-likeprovided by MGI
Primary source: MGI:MGI:1922908
See related: Ensembl:ENSMUSG00000054582 AllianceGenome:MGI:1922908
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Epab; 1810053B01Rik
Summary: Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Acts upstream of or within several processes, including chromatin organization; mRNA polyadenylation; and oocyte maturation. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in early conceptus and gonad. Orthologous to human PABPC1L (poly(A) binding protein cytoplasmic 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 2.9), ovary adult (RPKM 2.7) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 H3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (163866685..163892458)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (164024770..164050538)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Superovulation with low or high doses of gonadotropins significantly altered Epab and Pabpc1 mRNA levels in GV oocytes, MII oocytes and 1- and 2-cell embryos compared with their respective controls. These changes most likely lead to variations in expression of EPAB- and PABPC1-regulated genes, which may adversely influence the quality of oocytes and early embryos retrieved using superovulation.
Title: Superovulation alters embryonic poly(A)-binding protein (Epab) and poly(A)-binding protein, cytoplasmic 1 (Pabpc1) gene expression in mouse oocytes and early embryos.
These findings suggest that EPAB may predominantly play roles in translational regulation of the mRNAs during early oogenesis and folliculogenesis, but PABPC1 most likely perform these roles in the later terms of ovarian development along with EPAB
Title: Epab and Pabpc1 are differentially expressed in the postnatal mouse ovaries.
In mature testis the highest levels of Epab are in spermatogonia, while Pabpc1 expression is detected in spermatocytes and round spermatids.
Title: Epab and Pabpc1 are differentially expressed during male germ cell development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

1810053B01Rik (e-PCR), detects polymorphism
- UniSTS:516575

1810053B01Rik (e-PCR), detects polymorphism
- UniSTS:516576

D20S528E (e-PCR)
- UniSTS:150763

Homology

Homologs of the Pabpc1l gene: The Pabpc1l gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.
Orthologs from Annotation Pipeline: 322 organisms have orthologs with human gene Pabpc1l
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables poly(A) binding	TAS Traceable Author Statement more info	PubMed
enables poly(U) RNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA polyadenylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nucleus localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oocyte maturation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transcription initiation-coupled chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: polyadenylate-binding protein 1-like

Names: embryonic poly(A)-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114079.2 → NP_001107551.1 polyadenylate-binding protein 1-like

See identical proteins and their annotated locations for NP_001107551.1

Status: VALIDATED

Source sequence(s)

AL591542, EU669908

Consensus CDS

CCDS50792.1

UniProtKB/TrEMBL

A2A5N3

Related

ENSMUSP00000096701.4, ENSMUST00000067715.5

Conserved Domains (6) summary

TIGR01628
Location:11 → 596

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12378
Location:12 → 91

RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins

cd12379
Location:97 → 172

RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins

cd12380
Location:190 → 269

RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins

cd12381
Location:293 → 370

RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins

pfam00658
Location:529 → 595

PABP; Poly-adenylate binding protein, unique domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

163866685..163892458

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499829.5 → XP_006499892.1 polyadenylate-binding protein 1-like isoform X2

Conserved Domains (1) summary

TIGR01628
Location:11 → 324

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
XM_036162344.1 → XP_036018237.1 polyadenylate-binding protein 1-like isoform X1

Conserved Domains (1) summary

TIGR01628
Location:1 → 458

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family