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Lonrf2 LON peptidase N-terminal domain and ring finger 2 [ Mus musculus (house mouse) ]

Gene ID: 381338, updated on 30-Apr-2024

Summary

Official Symbol
Lonrf2provided by MGI
Official Full Name
LON peptidase N-terminal domain and ring finger 2provided by MGI
Primary source
MGI:MGI:1920209
See related
Ensembl:ENSMUSG00000048814 AllianceGenome:MGI:1920209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900060P06Rik
Summary
Is expressed in central nervous system; ganglia; and neural retina. Orthologous to human LONRF2 (LON peptidase N-terminal domain and ring finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 27.9), whole brain E14.5 (RPKM 19.4) and 8 other tissues See more
Orthologs
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Genomic context

See Lonrf2 in Genome Data Viewer
Location:
1 B; 1 17.17 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (38832750..38875768, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (38793669..38836687, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene AF4/FMR2 family, member 3 Neighboring gene STARR-seq mESC enhancer starr_00698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:38714500-38714733 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:38721813-38722000 Neighboring gene predicted gene, 34596 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:38752992-38753101 Neighboring gene predicted gene, 57569 Neighboring gene STARR-seq mESC enhancer starr_00700 Neighboring gene STARR-positive B cell enhancer ABC_E8770 Neighboring gene STARR-seq mESC enhancer starr_00701 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:38942945-38943098 Neighboring gene carbohydrate sulfotransferase 10 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
LON peptidase N-terminal domain and RING finger protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029878.2NP_001025049.2  LON peptidase N-terminal domain and RING finger protein 2

    Status: VALIDATED

    Source sequence(s)
    AC124699
    Consensus CDS
    CCDS14900.2
    UniProtKB/TrEMBL
    F6ZE64
    Related
    ENSMUSP00000117600.3, ENSMUST00000147695.9
    Conserved Domains (5) summary
    sd00006
    Location:223253
    TPR; TPR repeat [structural motif]
    pfam02190
    Location:538738
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
    cd16513
    Location:136161
    RING1-HC_LONFs; RING finger 1, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
    cd16514
    Location:446487
    RING2-HC_LONFs; RING finger 2, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
    pfam13432
    Location:2790
    TPR_16; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    38832750..38875768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028403.1: Suppressed sequence

    Description
    NM_028403.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: LONRF2 (GeneID:164832).