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galene [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38133, updated on 5-Jan-2023

Summary

Official Symbol
galeneprovided by FlyBase
Primary source
FLYBASE:FBgn0035192
Locus tag
Dmel_CG9194
See related
AllianceGenome:FB:FBgn0035192
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0109301.19; anon-WO0109301.20; anon-WO0109301.21; anon-WO0109301.22; anon-WO0109301.23; anon-WO0109301.24; anon-WO0109301.25; anon-WO0109301.26; anon-WO0109301.27; anon-WO0109301.28; anon-WO0109301.29; anon-WO0109301.3; anon-WO0109301.31; anon-WO0109301.32; anon-WO0109301.33; anon-WO0109301.34; anon-WO0109301.36; anon-WO0109301.37; anon-WO0109301.38; C9194; CG9194; Dmel\CG9194
Summary
Predicted to enable potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in dorsal pharyngeal muscle cell; embryonic/larval muscle system; and embryonic/larval somatic muscle cell. Used to study heart conduction disease. Human ortholog(s) of this gene implicated in migraine with aura. Orthologous to human KCNK18 (potassium two pore domain channel subfamily K member 18). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See galene in Genome Data Viewer
Location:
61F4-61F4; 3-0 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1235726..1242025)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1235726..1242025)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45747 Neighboring gene uncharacterized protein Neighboring gene Kinesin-like protein at 61F Neighboring gene uncharacterized protein Neighboring gene Partner of Sld Five 1

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
galene
Names
CG9194-PA
galene-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1235726..1242025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138240.2NP_612084.1  galene [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612084.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W0J0
    Related
    FBpp0072545, FBtr0072651
    Conserved Domains (3) summary
    pfam06390
    Location:341586
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    pfam00520
    Location:621709
    Ion_trans; Ion transport protein
    pfam07885
    Location:134189
    Ion_trans_2; Ion channel