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Rc3h1 RING CCCH (C3H) domains 1 [ Mus musculus (house mouse) ]

Gene ID: 381305, updated on 8-Feb-2024

Summary

Official Symbol
Rc3h1provided by MGI
Official Full Name
RING CCCH (C3H) domains 1provided by MGI
Primary source
MGI:MGI:2685397
See related
Ensembl:ENSMUSG00000040423 AllianceGenome:MGI:2685397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm551; mKIAA2025; 5730557L09Rik
Summary
Enables RNA binding activity and zinc ion binding activity. Involved in several processes, including P-body assembly; negative regulation of lymphocyte activation; and regulation of RNA metabolic process. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; lymphocyte homeostasis; and positive regulation of NIK/NF-kappaB signaling. Located in P-body and cytoplasmic stress granule. Used to study peripheral T-cell lymphoma and systemic lupus erythematosus. Orthologous to human RC3H1 (ring finger and CCCH-type domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 5.7), thymus adult (RPKM 5.0) and 28 other tissues See more
Orthologs
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Genomic context

See Rc3h1 in Genome Data Viewer
Location:
1 H2.1; 1 69.75 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (160733981..160802546)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (160906411..160974976)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24988 Neighboring gene STARR-positive B cell enhancer mm9_chr1:162836371-162836672 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 Neighboring gene predicted gene, 57574 Neighboring gene zinc finger and BTB domain containing 37 Neighboring gene STARR-positive B cell enhancer mm9_chr1:162964993-162965294 Neighboring gene growth arrest specific 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CCR4-NOT complex binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA stem-loop binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA stem-loop binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA stem-loop binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in 3'-UTR-mediated mRNA destabilization TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within B cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in P-body assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T follicular helper cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to interleukin-1 TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within lymph node development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T-helper 17 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T-helper cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of germinal center formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of mRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within post-transcriptional regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of germinal center formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of miRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spleen development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
roquin-1
Names
RING finger and C3H zinc finger protein 1
RING finger and CCCH-type zinc finger domain-containing protein 1
probable E3 ubiquitin-protein ligase Roquin
protein Sanroque
roquin
NP_001020123.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024952.2NP_001020123.1  roquin-1

    See identical proteins and their annotated locations for NP_001020123.1

    Status: VALIDATED

    Source sequence(s)
    AC119204, AY948287, CJ133431
    Consensus CDS
    CCDS15410.1
    UniProtKB/Swiss-Prot
    B2RS13, Q4VGL6, Q69Z31
    UniProtKB/TrEMBL
    Q3UT88
    Related
    ENSMUSP00000124871.2, ENSMUST00000161609.8
    Conserved Domains (2) summary
    smart00184
    Location:1452
    RING; Ring finger
    pfam00642
    Location:414440
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    160733981..160802546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)