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Kif14 kinesin family member 14 [ Mus musculus (house mouse) ]

Gene ID: 381293, updated on 26-Sep-2022

Summary

Official Symbol
Kif14provided by MGI
Official Full Name
kinesin family member 14provided by MGI
Primary source
MGI:MGI:1098226
See related
Ensembl:ENSMUSG00000041498 AllianceGenome:MGI:1098226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D1Ertd367e; E130203M01
Summary
Enables ATP binding activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including brain development; negative regulation of neuron apoptotic process; and regulation of myelination. Predicted to be located in Flemming body; cytosol; and spindle midzone. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Predicted to colocalize with plasma membrane. Is expressed in retina. Human ortholog(s) of this gene implicated in Meckel syndrome and primary autosomal recessive microcephaly. Orthologous to human KIF14 (kinesin family member 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 3.3), liver E14.5 (RPKM 2.8) and 14 other tissues See more
Orthologs
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Genomic context

See Kif14 in Genome Data Viewer
Location:
1 E4; 1 59.8 cM
Exon count:
39
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (136394044..136483676)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (136466301..136555938)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene calmodulin regulated spectrin-associated protein family, member 2 Neighboring gene RIKEN cDNA 9230116N13 gene Neighboring gene DEAD box helicase 59 Neighboring gene predicted gene 29485 Neighboring gene zinc finger protein 281 Neighboring gene predicted gene, 34056 Neighboring gene predicted gene, 41958

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC189899

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables plus-end-directed microtubule motor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell proliferation in forebrain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebellar Purkinje cell layer structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebellar cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebellar granular layer structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of protein localization ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in microtubule depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of integrin activation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in olfactory bulb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of Rap protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinesin-like protein KIF14
Names
N-3 kinesin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287179.2NP_001274108.1  kinesin-like protein KIF14

    See identical proteins and their annotated locations for NP_001274108.1

    Status: VALIDATED

    Source sequence(s)
    AB731728, AC122127, AC126606, AK087451
    Consensus CDS
    CCDS78693.1
    UniProtKB/Swiss-Prot
    L0N7N1
    Related
    ENSMUSP00000139698.2, ENSMUST00000189413.7
    Conserved Domains (5) summary
    cd00060
    Location:838935
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02168
    Location:9371109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01365
    Location:392743
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam05110
    Location:161384
    AF-4; AF-4 proto-oncoprotein
    pfam16183
    Location:740859
    Kinesin_assoc; Kinesin-associated

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    136394044..136483676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248046.3XP_011246348.1  kinesin-like protein KIF14 isoform X2

    Conserved Domains (5) summary
    cd00060
    Location:838935
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02168
    Location:9371109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01365
    Location:392743
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam05110
    Location:161384
    AF-4; AF-4 proto-oncoprotein
    pfam16183
    Location:740859
    Kinesin_assoc; Kinesin-associated
  2. XM_011248039.3XP_011246341.1  kinesin-like protein KIF14 isoform X1

    See identical proteins and their annotated locations for XP_011246341.1

    Conserved Domains (5) summary
    cd00060
    Location:838935
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02168
    Location:9371109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01365
    Location:392743
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam05110
    Location:161384
    AF-4; AF-4 proto-oncoprotein
    pfam16183
    Location:740859
    Kinesin_assoc; Kinesin-associated
  3. XM_011248040.3XP_011246342.1  kinesin-like protein KIF14 isoform X1

    See identical proteins and their annotated locations for XP_011246342.1

    Conserved Domains (5) summary
    cd00060
    Location:838935
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02168
    Location:9371109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01365
    Location:392743
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam05110
    Location:161384
    AF-4; AF-4 proto-oncoprotein
    pfam16183
    Location:740859
    Kinesin_assoc; Kinesin-associated
  4. XM_011248044.3XP_011246346.1  kinesin-like protein KIF14 isoform X1

    See identical proteins and their annotated locations for XP_011246346.1

    Conserved Domains (5) summary
    cd00060
    Location:838935
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02168
    Location:9371109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01365
    Location:392743
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam05110
    Location:161384
    AF-4; AF-4 proto-oncoprotein
    pfam16183
    Location:740859
    Kinesin_assoc; Kinesin-associated
  5. XM_011248043.4XP_011246345.1  kinesin-like protein KIF14 isoform X1

    See identical proteins and their annotated locations for XP_011246345.1

    Conserved Domains (5) summary
    cd00060
    Location:838935
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02168
    Location:9371109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01365
    Location:392743
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam05110
    Location:161384
    AF-4; AF-4 proto-oncoprotein
    pfam16183
    Location:740859
    Kinesin_assoc; Kinesin-associated
  6. XM_006529729.5XP_006529792.1  kinesin-like protein KIF14 isoform X3

    See identical proteins and their annotated locations for XP_006529792.1

    UniProtKB/Swiss-Prot
    L0N7N1
    Conserved Domains (5) summary
    cd00060
    Location:838935
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02168
    Location:9371109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01365
    Location:392743
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam05110
    Location:161384
    AF-4; AF-4 proto-oncoprotein
    pfam16183
    Location:740859
    Kinesin_assoc; Kinesin-associated
  7. XM_006529730.3XP_006529793.2  kinesin-like protein KIF14 isoform X1

    See identical proteins and their annotated locations for XP_006529793.2

    Conserved Domains (5) summary
    cd00060
    Location:838935
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02168
    Location:9371109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01365
    Location:392743
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam05110
    Location:161384
    AF-4; AF-4 proto-oncoprotein
    pfam16183
    Location:740859
    Kinesin_assoc; Kinesin-associated

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081258.1: Suppressed sequence

    Description
    NM_001081258.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.