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Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 [ Mus musculus (house mouse) ]

Gene ID: 381290, updated on 9-Mar-2023

Summary

Official Symbol
Atp2b4provided by MGI
Official Full Name
ATPase, Ca++ transporting, plasma membrane 4provided by MGI
Primary source
MGI:MGI:88111
See related
Ensembl:ENSMUSG00000026463 AllianceGenome:MGI:88111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pmca4
Summary
Enables scaffold protein binding activity and sodium channel regulator activity. Involved in several processes, including negative regulation of blood vessel endothelial cell migration; negative regulation of calcineurin-NFAT signaling cascade; and negative regulation of cardiac muscle hypertrophy in response to stress. Located in T-tubule and sperm flagellum. Part of protein-containing complex. Is expressed in several structures, including bladder; heart; intestine wall; liver; and nervous system. Orthologous to human ATP2B4 (ATPase plasma membrane Ca2+ transporting 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 55.6), genital fat pad adult (RPKM 33.8) and 22 other tissues See more
Orthologs
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Genomic context

See Atp2b4 in Genome Data Viewer
Location:
1 E4; 1 57.95 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133630411..133728797, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133702674..133801059, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH type containing 11A Neighboring gene zinc finger, BED type containing 6 Neighboring gene lymphocyte transmembrane adaptor 1 Neighboring gene microRNA 6903 Neighboring gene predicted gene, 53476 Neighboring gene predicted gene, 41954 Neighboring gene predicted gene 28441 Neighboring gene predicted gene, 31515

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129362, MGC129363

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables P-type calcium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables P-type calcium transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
enables nitric-oxide synthase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 2B binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in calcium ion export ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to acetylcholine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to epinephrine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of arginine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle hypertrophy in response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac muscle hypertrophy in response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of citrulline biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-cysteine S-nitrosylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of sodium ion transmembrane transport IC
Inferred by Curator
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hydrostatic pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in urinary bladder smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm principal piece ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
plasma membrane calcium-transporting ATPase 4
NP_001161421.1
NP_998781.1
XP_006529786.1
XP_006529787.1
XP_006529788.1
XP_006529789.1
XP_006529790.1
XP_006529791.1
XP_011246340.1
XP_030111006.1
XP_030111007.1
XP_030111009.1
XP_030111013.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167949.2NP_001161421.1  plasma membrane calcium-transporting ATPase 4 isoform a

    See identical proteins and their annotated locations for NP_001161421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a, also known as x/e or PMCA4a) represents the longer transcript but encodes the shorter isoform (a).
    Source sequence(s)
    AC124338, AK143672, BC109172, CJ240063, EU493094
    Consensus CDS
    CCDS48365.1
    UniProtKB/Swiss-Prot
    Q6Q477
    UniProtKB/TrEMBL
    D1FNM8, F7AAP4, Q3UPA8
    Related
    ENSMUSP00000047978.8, ENSMUST00000048953.14
    Conserved Domains (2) summary
    TIGR01517
    Location:161053
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10901127
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  2. NM_213616.4NP_998781.1  plasma membrane calcium-transporting ATPase 4 isoform b

    See identical proteins and their annotated locations for NP_998781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b, also known as x/b or PMCA4b) lacks an alternate exon which results in an alternate 3' coding region, compared to variant a. The encoded isoform (b) has a distinct and longer C-terminus, compared to isoform a.
    Source sequence(s)
    AC124338, AK143672, BC109172, CJ240063, EU493095
    Consensus CDS
    CCDS15298.1
    UniProtKB/Swiss-Prot
    Q32ME1, Q6Q477
    UniProtKB/TrEMBL
    D1FNM9, Q3UPA8
    Related
    ENSMUSP00000133187.3, ENSMUST00000165602.9
    Conserved Domains (2) summary
    TIGR01517
    Location:161053
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10901135
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    133630411..133728797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529723.4XP_006529786.1  plasma membrane calcium-transporting ATPase 4 isoform X1

    See identical proteins and their annotated locations for XP_006529786.1

    UniProtKB/Swiss-Prot
    Q32ME1, Q6Q477
    Related
    ENSMUSP00000119242.2, ENSMUST00000143567.8
    Conserved Domains (2) summary
    TIGR01517
    Location:161053
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10901135
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  2. XM_011248038.3XP_011246340.1  plasma membrane calcium-transporting ATPase 4 isoform X9

    Conserved Domains (2) summary
    TIGR01517
    Location:161053
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10901169
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  3. XM_006529727.4XP_006529790.1  plasma membrane calcium-transporting ATPase 4 isoform X3

    UniProtKB/TrEMBL
    E9Q828
    Related
    ENSMUSP00000116941.2, ENSMUST00000125659.8
    Conserved Domains (2) summary
    TIGR01517
    Location:161053
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10901127
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  4. XM_006529728.4XP_006529791.1  plasma membrane calcium-transporting ATPase 4 isoform X4

    See identical proteins and their annotated locations for XP_006529791.1

    UniProtKB/TrEMBL
    F7AAP4
    Conserved Domains (2) summary
    TIGR01517
    Location:161053
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10901127
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  5. XM_006529724.4XP_006529787.1  plasma membrane calcium-transporting ATPase 4 isoform X1

    See identical proteins and their annotated locations for XP_006529787.1

    UniProtKB/Swiss-Prot
    Q32ME1, Q6Q477
    Conserved Domains (2) summary
    TIGR01517
    Location:161053
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10901135
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  6. XM_006529725.2XP_006529788.1  plasma membrane calcium-transporting ATPase 4 isoform X1

    See identical proteins and their annotated locations for XP_006529788.1

    UniProtKB/Swiss-Prot
    Q32ME1, Q6Q477
    Conserved Domains (2) summary
    TIGR01517
    Location:161053
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10901135
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  7. XM_030255147.2XP_030111007.1  plasma membrane calcium-transporting ATPase 4 isoform X6

    Conserved Domains (2) summary
    TIGR01517
    Location:1799
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:836881
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  8. XM_006529726.4XP_006529789.1  plasma membrane calcium-transporting ATPase 4 isoform X2

    Conserved Domains (2) summary
    TIGR01517
    Location:161041
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10781123
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  9. XM_030255149.2XP_030111009.1  plasma membrane calcium-transporting ATPase 4 isoform X7

    Conserved Domains (2) summary
    TIGR01517
    Location:1683
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:720765
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  10. XM_030255146.2XP_030111006.1  plasma membrane calcium-transporting ATPase 4 isoform X5

    Related
    ENSMUSP00000107883.2, ENSMUST00000112264.2
    Conserved Domains (2) summary
    TIGR01517
    Location:161041
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10781115
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  11. XM_030255153.1XP_030111013.1  plasma membrane calcium-transporting ATPase 4 isoform X8

    Conserved Domains (2) summary
    TIGR01517
    Location:1683
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:720757
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal