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Mreg melanoregulin [ Mus musculus (house mouse) ]

Gene ID: 381269, updated on 14-May-2024

Summary

Official Symbol
Mregprovided by MGI
Official Full Name
melanoregulinprovided by MGI
Primary source
MGI:MGI:2151839
See related
Ensembl:ENSMUSG00000039395 AllianceGenome:MGI:2151839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dsu; Wdt2; Gm974
Summary
Enables phosphatidylinositol binding activity. Involved in melanosome localization; minus-end-directed organelle transport along microtubule; and phagosome maturation. Acts upstream of or within melanocyte differentiation and melanosome transport. Located in late endosome membrane and melanosome membrane. Is intrinsic component of organelle membrane. Part of protein-containing complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; liver; and lung. Orthologous to human MREG (melanoregulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 12.4), placenta adult (RPKM 7.2) and 20 other tissues See more
Orthologs
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Genomic context

See Mreg in Genome Data Viewer
Location:
1 C3; 1 36.39 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (72198392..72251418, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (72159233..72212314, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15 pseudogene Neighboring gene predicted gene 4319 Neighboring gene STARR-positive B cell enhancer ABC_E4320 Neighboring gene STARR-seq mESC enhancer starr_01266 Neighboring gene predicted gene, 51630 Neighboring gene predicted gene, 25360

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Spontaneous (1)  1 citation
  • Targeted (2) 

General gene information

Markers

Clone Names

  • MGC92980

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in melanosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in melanosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in melanosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in organelle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
melanoregulin
Names
dilute suppressor protein
whn-dependent transcript 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005423.3NP_001005423.1  melanoregulin isoform 1

    See identical proteins and their annotated locations for NP_001005423.1

    Status: VALIDATED

    Source sequence(s)
    AC120136
    Consensus CDS
    CCDS15032.1
    UniProtKB/Swiss-Prot
    Q6NVG5
    Related
    ENSMUSP00000041878.8, ENSMUST00000048860.9
    Conserved Domains (1) summary
    pfam15812
    Location:46191
    MREG; Melanoregulin
  2. NM_001357488.2NP_001344417.1  melanoregulin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120136
    Conserved Domains (1) summary
    pfam15812
    Location:20165
    MREG; Melanoregulin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    72198392..72251418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496111.2XP_006496174.1  melanoregulin isoform X1

    See identical proteins and their annotated locations for XP_006496174.1

    Conserved Domains (1) summary
    pfam15812
    Location:20165
    MREG; Melanoregulin