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Kmt2d lysine (K)-specific methyltransferase 2D [ Mus musculus (house mouse) ]

Gene ID: 381022, updated on 3-Jun-2024

Summary

Official Symbol
Kmt2dprovided by MGI
Official Full Name
lysine (K)-specific methyltransferase 2Dprovided by MGI
Primary source
MGI:MGI:2682319
See related
Ensembl:ENSMUSG00000048154 AllianceGenome:MGI:2682319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ALR; Mll2; Mll4; bapa; KMT2B; C430014K11Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in heterochromatin assembly; histone H3-K4 methylation; and oocyte growth. Acts upstream of or within in utero embryonic development and regulation of gene expression. Predicted to be located in nucleoplasm. Predicted to be part of MLL3/4 complex. Is expressed in several structures, including central nervous system; cranium; heart; integumental system; and sensory organ. Used to study Kabuki syndrome. Human ortholog(s) of this gene implicated in Kabuki syndrome and esophagus squamous cell carcinoma. Orthologous to human KMT2D (lysine methyltransferase 2D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 25.1), spleen adult (RPKM 21.8) and 27 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See Kmt2d in Genome Data Viewer
Location:
15 F1; 15
Exon count:
57
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98729550..98771958, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98831669..98874077, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene dendrin Neighboring gene protein kinase, AMP-activated, gamma 1 non-catalytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E1918 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98663163-98663346 Neighboring gene STARR-seq mESC enhancer starr_39676 Neighboring gene STARR-positive B cell enhancer ABC_E10880 Neighboring gene Ras homolog enriched in brain like 1 Neighboring gene desert hedgehog

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3K4 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H3K4 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone H3K4 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of MLL3/4 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of MLL3/4 complex ISO
Inferred from Sequence Orthology
more info
 
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone-lysine N-methyltransferase 2D
Names
ALL1-related protein
histone-lysine N-methyltransferase MLL2
lysine N-methyltransferase 2B
lysine N-methyltransferase 2D
myeloid/lymphoid or mixed-lineage leukemia 2
myeloid/lymphoid or mixed-lineage leukemia protein 2
NP_001028448.3
XP_017172163.1
XP_017172164.1
XP_017172165.1
XP_017172166.1
XP_017172167.1
XP_017172168.1
XP_017172169.1
XP_017172170.1
XP_017172171.1
XP_017172172.1
XP_017172173.1
XP_030104483.1
XP_030104484.1
XP_036015372.1
XP_036015373.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033276.3NP_001028448.3  histone-lysine N-methyltransferase 2D

    Status: VALIDATED

    Source sequence(s)
    AC161165
    Consensus CDS
    CCDS49725.2
    UniProtKB/Swiss-Prot
    Q6PDK2
    UniProtKB/TrEMBL
    A0A0A0MQ73
    Related
    ENSMUSP00000023741.9, ENSMUST00000023741.16
    Conserved Domains (11) summary
    smart00398
    Location:19782029
    HMG; high mobility group
    smart00542
    Location:52915378
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:54485570
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd15509
    Location:228273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13851431
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13341384
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14621512
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:50835189
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:52335283
    FYRN; F/Y-rich N-terminus
    cl22851
    Location:275320
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98729550..98771958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316684.2XP_017172173.1  histone-lysine N-methyltransferase 2D isoform X15

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:19792030
    HMG; high mobility group
    smart00542
    Location:52925379
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:20682634
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13861432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13351385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14631513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:50845190
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:52335284
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:54345588
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275320
    PHD_SF; PHD finger superfamily
  2. XM_017316674.2XP_017172163.1  histone-lysine N-methyltransferase 2D isoform X1

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:19822033
    HMG; high mobility group
    smart00542
    Location:52955382
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:20712637
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13861432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13351385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14631513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:50875193
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:52365287
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:54535607
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275320
    PHD_SF; PHD finger superfamily
  3. XM_017316680.2XP_017172169.1  histone-lysine N-methyltransferase 2D isoform X9

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:19762027
    HMG; high mobility group
    smart00542
    Location:52895376
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:20652631
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13851431
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13341384
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14621512
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:50815187
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:52305281
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:54475601
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275320
    PHD_SF; PHD finger superfamily
  4. XM_030248623.1XP_030104483.1  histone-lysine N-methyltransferase 2D isoform X7

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:19782029
    HMG; high mobility group
    smart00542
    Location:52915378
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:20672633
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13851431
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13341384
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14621512
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:50835189
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:52325283
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:54495603
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275320
    PHD_SF; PHD finger superfamily
  5. XM_017316675.2XP_017172164.1  histone-lysine N-methyltransferase 2D isoform X2

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:19812032
    HMG; high mobility group
    smart00542
    Location:52945381
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:20702636
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13851431
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13341384
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14621512
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:50865192
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:52355286
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:54525606
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275320
    PHD_SF; PHD finger superfamily
  6. XM_036159479.1XP_036015372.1  histone-lysine N-methyltransferase 2D isoform X12

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:19081959
    HMG; high mobility group
    smart00542
    Location:52215308
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:19972563
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13861432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13351385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14631513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:50135119
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd19209
    Location:53795533
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    pfam05964
    Location:51625213
    FYRN; F/Y-rich N-terminus
    cl22851
    Location:275320
    PHD_SF; PHD finger superfamily
  7. XM_030248624.1XP_030104484.1  histone-lysine N-methyltransferase 2D isoform X8

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:19772028
    HMG; high mobility group
    smart00542
    Location:52905377
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:20662632
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13861432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13351385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14631513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:50825188
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:52315282
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:54485602
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275320
    PHD_SF; PHD finger superfamily
  8. XM_017316678.2XP_017172167.1  histone-lysine N-methyltransferase 2D isoform X5

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:19802031
    HMG; high mobility group
    smart00542
    Location:52935380
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:20692635
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13861432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13351385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14631513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:50855191
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:52345285
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:54515605
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275320
    PHD_SF; PHD finger superfamily
  9. XM_017316679.2XP_017172168.1  histone-lysine N-methyltransferase 2D isoform X6

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:19792030
    HMG; high mobility group
    smart00542
    Location:52925379
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:20682634
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13861432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13351385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14631513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:50845190
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:52335284
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:54505604
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275320
    PHD_SF; PHD finger superfamily
  10. XM_017316681.2XP_017172170.1  histone-lysine N-methyltransferase 2D isoform X10

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:19752026
    HMG; high mobility group
    smart00542
    Location:52885375
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:20642630
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13861432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13351385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14631513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:50805186
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:52295280
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:54465600
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275320
    PHD_SF; PHD finger superfamily
  11. XM_017316677.2XP_017172166.1  histone-lysine N-methyltransferase 2D isoform X4

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:19822033
    HMG; high mobility group
    smart00542
    Location:52945381
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:20702636
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13861432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13351385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14631513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:50865192
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:52355286
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:54525606
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275320
    PHD_SF; PHD finger superfamily
  12. XM_017316682.2XP_017172171.1  histone-lysine N-methyltransferase 2D isoform X11

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:19822033
    HMG; high mobility group
    smart00542
    Location:52955382
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:20712637
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13861432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13351385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14631513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:50875193
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:52365287
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:54375591
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275320
    PHD_SF; PHD finger superfamily
  13. XM_017316676.2XP_017172165.1  histone-lysine N-methyltransferase 2D isoform X3

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:19812032
    HMG; high mobility group
    smart00542
    Location:52945381
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:20702636
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:227272
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13851431
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13341384
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14621512
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:133216
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:50865192
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:52355286
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:54525606
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:274319
    PHD_SF; PHD finger superfamily
  14. XM_036159480.1XP_036015373.1  histone-lysine N-methyltransferase 2D isoform X14

    Conserved Domains (6) summary
    smart00398
    Location:356407
    HMG; high mobility group
    smart00542
    Location:36693756
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:4451011
    PHA03247; large tegument protein UL36; Provisional
    cd15698
    Location:34613567
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd19209
    Location:38273981
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    pfam05964
    Location:36103661
    FYRN; F/Y-rich N-terminus
  15. XM_017316683.3XP_017172172.1  histone-lysine N-methyltransferase 2D isoform X13

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (8) summary
    smart00398
    Location:19822033
    HMG; high mobility group
    PHA03247
    Location:20712637
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:13861432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:13351385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:14631513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cl22851
    Location:275320
    PHD_SF; PHD finger superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033388.1: Suppressed sequence

    Description
    NM_001033388.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.