U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfat zinc finger and AT hook domain containing [ Mus musculus (house mouse) ]

Gene ID: 380993, updated on 21-Apr-2024

Summary

Official Symbol
Zfatprovided by MGI
Official Full Name
zinc finger and AT hook domain containingprovided by MGI
Primary source
MGI:MGI:2681865
See related
Ensembl:ENSMUSG00000022335 AllianceGenome:MGI:2681865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm922; Zfat1; Zfp406
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Acts upstream of or within hematopoietic progenitor cell differentiation and spongiotrophoblast layer development. Predicted to be located in nucleus. Is expressed in several structures, including extraembryonic component; nervous system; and placenta. Human ortholog(s) of this gene implicated in autoimmune thyroiditis. Orthologous to human ZFAT (zinc finger and AT-hook domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 1.9), placenta adult (RPKM 1.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
15 D2; 15 29.44 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (67955563..68130771, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (68083714..68258922, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700012I11 gene Neighboring gene STARR-seq mESC enhancer starr_38899 Neighboring gene STARR-seq mESC enhancer starr_38900 Neighboring gene STARR-seq mESC enhancer starr_38902 Neighboring gene STARR-seq mESC enhancer starr_38903 Neighboring gene STARR-seq mESC enhancer starr_38904 Neighboring gene predicted gene, 53906 Neighboring gene STARR-seq mESC enhancer starr_38905 Neighboring gene STARR-positive B cell enhancer ABC_E7377 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene predicted gene 20732 Neighboring gene microRNA 30b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC56951

General protein information

Preferred Names
zinc finger protein ZFAT
Names
ZFAT zinc finger 1
zinc finger protein 403
zinc finger protein 406

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145888.2NP_001139360.1  zinc finger protein ZFAT isoform 1

    See identical proteins and their annotated locations for NP_001139360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC108821, AC126249, AC140212
    Consensus CDS
    CCDS49623.1
    UniProtKB/Swiss-Prot
    B2C322, Q7TS63
    UniProtKB/TrEMBL
    E0CX30
    Related
    ENSMUSP00000125257.2, ENSMUST00000160248.8
    Conserved Domains (4) summary
    sd00017
    Location:273293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:271293
    zf-C2H2; Zinc finger, C2H2 type
    pfam13909
    Location:299323
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam13465
    Location:285309
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001403039.1NP_001389968.1  zinc finger protein ZFAT isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108821, AC126249, AC140212
  3. NM_198644.3NP_941046.1  zinc finger protein ZFAT isoform 2

    See identical proteins and their annotated locations for NP_941046.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in both the 5' and 3' coding regions, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC108821, AC126249, AC140212
    Consensus CDS
    CCDS49624.1
    UniProtKB/TrEMBL
    E0CX30
    Related
    ENSMUSP00000125732.2, ENSMUST00000162054.9
    Conserved Domains (3) summary
    sd00017
    Location:266286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:264286
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:278300
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_152182.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC108821, AC126249, AC140212

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    67955563..68130771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521124.4XP_006521187.2  zinc finger protein ZFAT isoform X1

    UniProtKB/TrEMBL
    E0CX30
    Conserved Domains (3) summary
    sd00017
    Location:318338
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:316338
    zf-C2H2; Zinc finger, C2H2 type
    pfam13909
    Location:344368
    zf-H2C2_5; C2H2-type zinc-finger domain
  2. XM_030248622.2XP_030104482.1  zinc finger protein ZFAT isoform X3

    UniProtKB/TrEMBL
    E0CX30
    Conserved Domains (3) summary
    sd00017
    Location:261281
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:259281
    zf-C2H2; Zinc finger, C2H2 type
    pfam13909
    Location:287311
    zf-H2C2_5; C2H2-type zinc-finger domain
  3. XM_011245683.4XP_011243985.1  zinc finger protein ZFAT isoform X3

    UniProtKB/TrEMBL
    E0CX30
    Conserved Domains (3) summary
    sd00017
    Location:261281
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:259281
    zf-C2H2; Zinc finger, C2H2 type
    pfam13909
    Location:287311
    zf-H2C2_5; C2H2-type zinc-finger domain

RNA

  1. XR_003951402.2 RNA Sequence

  2. XR_004938848.1 RNA Sequence

  3. XR_004938847.1 RNA Sequence