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KIR2DS3 killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 [ Homo sapiens (human) ]

Gene ID: 3808, updated on 11-Jun-2021

Summary

Official Symbol
KIR2DS3provided by HGNC
Official Full Name
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3provided by HGNC
Primary source
HGNC:HGNC:6335
See related
MIM:604954
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKAT7
Summary
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Annotation information
Annotation category: only annotated on alternate loci and patches unit in reference assembly
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Genomic context

See KIR2DS3 in Genome Data Viewer
Location:
19q13.4
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_10) NT_187636.1 (150177..164532, complement)
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_14) NT_187640.1 (105638..119993, complement)
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_15) NT_187641.1 (49535..63891, complement)
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_22) NT_187670.1 (37647..52003, complement)
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_27) NT_187675.1 (81218..95573)
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (PATCHES) NW_016107303.1 (146131..160488)
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (PATCHES) NW_016107310.1 (70201..84556)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 (PATCHES) NW_003571055.1 (462393..476925)

NT_187636.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 Neighboring gene uncharacterized LOC101928804 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains pseudogene 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2

NT_187640.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 Neighboring gene uncharacterized LOC101928804 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains pseudogene 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2

NT_187641.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1

NT_187670.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1

NT_187675.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Neighboring gene killer cell immunoglobulin like receptor, two Ig domains pseudogene 1 Neighboring gene uncharacterized LOC101928804 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1

NW_016107310.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Neighboring gene uncharacterized LOC101928804 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains pseudogene 1

NW_016107303.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin-like receptor 3DS1-like Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Neighboring gene killer cell immunoglobulin like receptor, two Ig domains pseudogene 1-like Neighboring gene killer cell immunoglobulin-like receptor 2DL1-like

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular defense response TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
killer cell immunoglobulin-like receptor 2DS3
Names
MHC class I NK cell receptor
NKAT-7
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
natural killer cell inhibitory receptor
natural killer-associated transcript 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_005994.1 

    Range
    58673..73028
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012313.1NP_036445.1  killer cell immunoglobulin-like receptor 2DS3 precursor

    See identical proteins and their annotated locations for NP_036445.1

    Status: REVIEWED

    Source sequence(s)
    L76670
    UniProtKB/Swiss-Prot
    Q14952
    UniProtKB/TrEMBL
    K7QT50
    Conserved Domains (2) summary
    cd00096
    Location:2933
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28122
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107303.1 Reference GRCh38.p13 PATCHES

    Range
    146131..160488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107310.1 Reference GRCh38.p13 PATCHES

    Range
    70201..84556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_10

Genomic

  1. NT_187636.1 Reference GRCh38.p13 ALT_REF_LOCI_10

    Range
    150177..164532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_14

Genomic

  1. NT_187640.1 Reference GRCh38.p13 ALT_REF_LOCI_14

    Range
    105638..119993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_15

Genomic

  1. NT_187641.1 Reference GRCh38.p13 ALT_REF_LOCI_15

    Range
    49535..63891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_22

Genomic

  1. NT_187670.1 Reference GRCh38.p13 ALT_REF_LOCI_22

    Range
    37647..52003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_27

Genomic

  1. NT_187675.1 Reference GRCh38.p13 ALT_REF_LOCI_27

    Range
    81218..95573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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