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Ighd immunoglobulin heavy constant delta [ Mus musculus (house mouse) ]

Gene ID: 380797, updated on 26-Sep-2022

Summary

Official Symbol
Ighdprovided by MGI
Official Full Name
immunoglobulin heavy constant deltaprovided by MGI
Primary source
MGI:MGI:96447
See related
Ensembl:ENSMUSG00000104213 IMGT/GENE-DB:IGHD; AllianceGenome:MGI:96447
Gene type
other
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IgD; Igh-5
Summary
Enables antigen binding activity. Acts upstream of or within several processes, including immunoglobulin mediated immune response; positive regulation of B cell proliferation; and somatic hypermutation of immunoglobulin genes. Located in external side of plasma membrane. Part of B cell receptor complex. Orthologous to human IGHD (immunoglobulin heavy constant delta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Ighd in Genome Data Viewer
Location:
12 F1; 12 62.1 cM
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113371155..113379944, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113407535..113416324, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy chain complex Neighboring gene FUS interacting protein (serine-arginine rich) 1 pseudogene Neighboring gene transducin-like enhancer of split 6 pseudogene Neighboring gene transducin-like enhancer of split 6 pseudogene Neighboring gene immunoglobulin heavy joining 4 Neighboring gene immunoglobulin heavy constant mu

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (3) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Other Names

  • immunoglobulin delta-chain
  • immunoglobulin heavy chain 5 (delta-like heavy chain)

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables antigen binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of B cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis, recognition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-1 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of immune response IDA
Inferred from Direct Assay
more info
 
acts_upstream_of_or_within regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of B cell receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of immunoglobulin complex, circulating IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_005838.1 

    Range
    159939..168728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    113371155..113379944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)