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Rph3al rabphilin 3A-like (without C2 domains) [ Mus musculus (house mouse) ]

Gene ID: 380714, updated on 26-Sep-2022

Summary

Official Symbol
Rph3alprovided by MGI
Official Full Name
rabphilin 3A-like (without C2 domains)provided by MGI
Primary source
MGI:MGI:1923492
See related
Ensembl:ENSMUSG00000020847 AllianceGenome:MGI:1923492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Noc2; Gm1753
Summary
Predicted to enable LIM domain binding activity. Involved in glucose homeostasis and positive regulation of insulin secretion. Acts upstream of or within negative regulation of G protein-coupled receptor signaling pathway and regulation of calcium ion-dependent exocytosis. Predicted to be located in secretory granule membrane. Orthologous to human RPH3AL (rabphilin 3A like (without C2 domains)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 6.6), stomach adult (RPKM 5.2) and 21 other tissues See more
Orthologs
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Genomic context

See Rph3al in Genome Data Viewer
Location:
11; 11 B5
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75721818..75858440, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75830992..75967614, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118567335 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Neighboring gene double C2, beta Neighboring gene predicted gene 12339 Neighboring gene RIKEN cDNA 1700016K19 gene Neighboring gene refilin B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • 6530413F01Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables LIM domain binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
rab effector Noc2
Names
no C2 domains protein
rabphilin-3A-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291159.1NP_001278088.1  rab effector Noc2 isoform 2

    See identical proteins and their annotated locations for NP_001278088.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons, and uses an alternate 3'-terminal exon, compared to variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK018335, CO800159, DV653859
    Consensus CDS
    CCDS70243.1
    UniProtKB/Swiss-Prot
    Q768S4
    Related
    ENSMUSP00000021208.5, ENSMUST00000021208.11
    Conserved Domains (1) summary
    cl22851
    Location:45117
    PHD_SF; PHD finger superfamily
  2. NM_029548.4NP_083824.1  rab effector Noc2 isoform 1

    See identical proteins and their annotated locations for NP_083824.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA616014, AI594476, BQ176035, BU610075, BX631599, DV651301, DV660756
    Consensus CDS
    CCDS25058.1
    UniProtKB/Swiss-Prot
    Q768S4, Q9D353
    Related
    ENSMUSP00000064202.5, ENSMUST00000066504.11
    Conserved Domains (1) summary
    pfam02318
    Location:45159
    FYVE_2; FYVE-type zinc finger

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75721818..75858440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533643.2XP_006533706.1  rab effector Noc2 isoform X2

    Conserved Domains (1) summary
    cl22851
    Location:45130
    PHD_SF; PHD finger superfamily
  2. XM_006533637.2XP_006533700.1  rab effector Noc2 isoform X1

    See identical proteins and their annotated locations for XP_006533700.1

    UniProtKB/Swiss-Prot
    Q768S4, Q9D353
    Conserved Domains (1) summary
    pfam02318
    Location:45159
    FYVE_2; FYVE-type zinc finger
  3. XM_006533638.5XP_006533701.1  rab effector Noc2 isoform X1

    See identical proteins and their annotated locations for XP_006533701.1

    UniProtKB/Swiss-Prot
    Q768S4, Q9D353
    Related
    ENSMUSP00000113869.2, ENSMUST00000121287.8
    Conserved Domains (1) summary
    pfam02318
    Location:45159
    FYVE_2; FYVE-type zinc finger
  4. XM_006533640.5XP_006533703.1  rab effector Noc2 isoform X1

    See identical proteins and their annotated locations for XP_006533703.1

    UniProtKB/Swiss-Prot
    Q768S4, Q9D353
    Conserved Domains (1) summary
    pfam02318
    Location:45159
    FYVE_2; FYVE-type zinc finger
  5. XM_006533642.5XP_006533705.1  rab effector Noc2 isoform X1

    See identical proteins and their annotated locations for XP_006533705.1

    UniProtKB/Swiss-Prot
    Q768S4, Q9D353
    Conserved Domains (1) summary
    pfam02318
    Location:45159
    FYVE_2; FYVE-type zinc finger
  6. XM_030246103.1XP_030101963.1  rab effector Noc2 isoform X2

    Conserved Domains (1) summary
    cl22851
    Location:45130
    PHD_SF; PHD finger superfamily
  7. XM_006533639.4XP_006533702.1  rab effector Noc2 isoform X1

    See identical proteins and their annotated locations for XP_006533702.1

    UniProtKB/Swiss-Prot
    Q768S4, Q9D353
    Conserved Domains (1) summary
    pfam02318
    Location:45159
    FYVE_2; FYVE-type zinc finger
  8. XM_006533641.5XP_006533704.1  rab effector Noc2 isoform X1

    See identical proteins and their annotated locations for XP_006533704.1

    UniProtKB/Swiss-Prot
    Q768S4, Q9D353
    Conserved Domains (1) summary
    pfam02318
    Location:45159
    FYVE_2; FYVE-type zinc finger
  9. XM_011249100.3XP_011247402.1  rab effector Noc2 isoform X3

    Conserved Domains (1) summary
    pfam02318
    Location:45159
    FYVE_2; FYVE-type zinc finger
  10. XM_011249101.2XP_011247403.1  rab effector Noc2 isoform X4

    See identical proteins and their annotated locations for XP_011247403.1

    UniProtKB/Swiss-Prot
    Q768S4
    Conserved Domains (1) summary
    cl22851
    Location:45117
    PHD_SF; PHD finger superfamily
  11. XM_011249102.2XP_011247404.1  rab effector Noc2 isoform X4

    See identical proteins and their annotated locations for XP_011247404.1

    UniProtKB/Swiss-Prot
    Q768S4
    Related
    ENSMUSP00000104058.3, ENSMUST00000108420.9
    Conserved Domains (1) summary
    cl22851
    Location:45117
    PHD_SF; PHD finger superfamily

RNA

  1. XR_388486.2 RNA Sequence

  2. XR_003949467.2 RNA Sequence