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Lemd3 LEM domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 380664, updated on 24-Jan-2023

Summary

Official Symbol
Lemd3provided by MGI
Official Full Name
LEM domain containing 3provided by MGI
Primary source
MGI:MGI:3580376
See related
Ensembl:ENSMUSG00000048661 AllianceGenome:MGI:3580376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Man1
Summary
Predicted to enable chromatin DNA binding activity. Acts upstream of or within several processes, including blood vessel endothelial cell migration involved in intussusceptive angiogenesis; regulation of extracellular matrix organization; and skeletal muscle cell differentiation. Located in nuclear envelope. Is expressed in several structures, including allantois; foregut diverticulum endoderm; lateral plate mesoderm; neural plate; and primitive streak. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome. Orthologous to human LEMD3 (LEM domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 6.1), cerebellum adult (RPKM 5.6) and 28 other tissues See more
Orthologs
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Genomic context

See Lemd3 in Genome Data Viewer
Location:
10; 10 D2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (120759316..120815491, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (120923411..120979396, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene methionine sulfoxide reductase B3 Neighboring gene predicted gene 15910 Neighboring gene predicted gene 4473 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 50589 Neighboring gene predicted gene, 35235 Neighboring gene predicted gene, 40784 Neighboring gene Wnt inhibitory factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inner nuclear membrane protein Man1
Names
LEM domain-containing protein 3
integral inner nuclear membrane protein MAN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081193.2NP_001074662.2  inner nuclear membrane protein Man1

    Status: VALIDATED

    Source sequence(s)
    AC140381, AF112300, AI842096, AK140538, BC082610, BF458366
    Consensus CDS
    CCDS48703.1
    UniProtKB/Swiss-Prot
    Q9WU40
    UniProtKB/TrEMBL
    E9QP59
    Related
    ENSMUSP00000113103.2, ENSMUST00000119944.8
    Conserved Domains (3) summary
    cd12286
    Location:792883
    RRM_Man1; RNA recognition motif in inner nuclear membrane protein Man1 (Man1) and similar proteins
    pfam09402
    Location:576755
    MSC; Man1-Src1p-C-terminal domain
    cl02649
    Location:1048
    LEM; LEM (Lap2/Emerin/Man1) domain found in emerin, lamina-associated polypeptide 2 (LAP2), inner nuclear membrane protein Man1 and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    120759316..120815491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001779544.3 RNA Sequence

  2. XR_380414.5 RNA Sequence