mapk14.S mitogen-activated protein kinase 14 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mapk14.S
Official Full Name: mitogen-activated protein kinase 14 S homeolog
Primary source: Xenbase:XB-GENE-1018624
Locus tag: XELAEV_18014868mg
See related: EnsemblRapid:ENSXLAG00005001698 AllianceGenome:Xenbase:XB-GENE-1018624
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: p38; csbp; mxi2; sapk2; mapk14; sapk2a; mapk14a; p38-alpha
Summary: Predicted to enable MAP kinase activity. Predicted to act upstream of or within several processes, including p38MAPK cascade; positive regulation of cell differentiation; and positive regulation of myoblast fusion. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 2S

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (59273083..59369384)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (55222519..55319006)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cytochrome c microinjection induces p38 phosphorylation through caspase-3 activation, and caspase inhibition reduces p38 activation induced by osmostress, indicating that a positive feedback loop is engaged by hyperosmotic shock
Title: Basic Properties of the p38 Signaling Pathway in Response to Hyperosmotic Shock.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within p38MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within p38MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of myoblast fusion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitogen-activated protein kinase 14

Names: MAP kinase 14; MAP kinase 2; MAPK 14; MAPK p38; MPK2; Mitogen-activated protein kinase 2; mitogen-activated Mitogen-activated protein kinase 2; mitogen-activated protein kinase p38 alpha

NP_001080300.1

EC 2.7.11.24

XP_018103537.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086831.1 → NP_001080300.1 mitogen-activated protein kinase 14

See identical proteins and their annotated locations for NP_001080300.1

Status: PROVISIONAL

Source sequence(s)

X80751

UniProtKB/Swiss-Prot

P47812, Q5D076

UniProtKB/TrEMBL

A0A974DGZ3, D2KW21

Related

ENSXLAP00005005032.1, ENSXLAT00005005138.1

Conserved Domains (2) summary

cd07877
Location:7 → 351

STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)

smart00220
Location:25 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain