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usp12b.S ubiquitin specific peptidase 12b S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379981, updated on 5-Sep-2025
Official Symbol
usp12b.S
Official Full Name
ubiquitin specific peptidase 12b S homeolog
Primary source
Xenbase:XB-GENE-5749378
Locus tag
XELAEV_18042056mg
See related
EnsemblRapid:ENSXLAG00005005859 AllianceGenome:Xenbase:XB-GENE-5749378
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
usp46; usp46.S
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to act upstream of or within protein deubiquitination. [provided by Alliance of Genome Resources, Jul 2025]
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See usp12b.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
10
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (55734683..55767137, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (54640996..54650548, complement)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptor 12 Neighboring gene uncharacterized LOC121397743 Neighboring gene ras-like protein family member 11A-like Neighboring gene ligand of Numb protein X 2-like Neighboring gene caudal type homeobox 4 S homeolog

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. Joo HY, et al. J Biol Chem, 2011 Mar 4. PMID 21183687, Free PMC Article
  2. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we identified USP12 and USP46 as histone H2A and H2B deubiquitinases that regulate Xenopus development
    Title: Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC53480

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
ubiquitin specific peptidase 12b S homeolog
Names
ubiquitin specific peptidase 46 S homeolog
ubiquitin specific protease 46
NP_001080289.1
XP_041430034.1
XP_041430036.1
XP_041430037.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086820.1 → NP_001080289.1  ubiquitin specific peptidase 12b S homeolog

    See identical proteins and their annotated locations for NP_001080289.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044045
    UniProtKB/TrEMBL
    Q7ZXZ5
    Conserved Domains (1) summary
    cd02663
    Location:1 → 246
    Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    55734683..55767137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041574103.1 → XP_041430037.1  ubiquitin specific peptidase 12b S homeolog isoform X2

    UniProtKB/TrEMBL
    Q7ZXZ5
    Conserved Domains (1) summary
    cd02663
    Location:1 → 246
    Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  2. XM_041574100.1 → XP_041430034.1  ubiquitin specific peptidase 12b S homeolog isoform X1

    UniProtKB/Swiss-Prot
    Q5M981
    UniProtKB/TrEMBL
    A0A8J1LLL0
    Related
    ENSXLAP00005017604.1, ENSXLAT00005017899.1
    Conserved Domains (1) summary
    cd02663
    Location:40 → 366
    Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  3. XM_041574102.1 → XP_041430036.1  ubiquitin specific peptidase 12b S homeolog isoform X2

    UniProtKB/TrEMBL
    Q7ZXZ5
    Conserved Domains (1) summary
    cd02663
    Location:1 → 246
    Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
Nucleotide Protein Strain
Heading Accession and Version

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