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Ance-5 Ance-5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37980, updated on 8-Apr-2026
Official Symbol
Ance-5provided by FlyBase
Official Full Name
Ance-5provided by FlyBase
Primary source
FLYBASE:FBgn0035076
Locus tag
Dmel_CG10142
See related
AllianceGenome:FB:FBgn0035076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ance-5; CG10142; Dmel\CG10142
Summary
Predicted to be located in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See Ance-5 in Genome Data Viewer
Location:
60E5-60E5; 2-107 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24888628..24891023, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20776151..20778546, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43466 Neighboring gene Na,K-ATPase Interacting Neighboring gene Na channel protein 60E Neighboring gene uncharacterized protein Neighboring gene Thiamine pyrophosphate carrier protein 2 Neighboring gene Ribosomal protein L41

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Deciphering mechanisms of action of ACE inhibitors in neurodegeneration using Drosophila models of Alzheimer's disease. Ghalayini J, et al. Front Neurosci, 2023. PMID 37113150, Free PMC Article
  2. ACE and ACE2: insights from Drosophila and implications for COVID-19. Herrera P, et al. Heliyon, 2021 Dec. PMID 34901515, Free PMC Article
  3. Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme. Coates D, et al. Biochemistry, 2000 Aug 1. PMID 10913309
  4. A conserved gene cluster as a putative functional unit in insect innate immunity. Somogyi K, et al. FEBS Lett, 2010 Nov 5. PMID 20951134
  5. Socially-responsive gene expression in male Drosophila melanogaster is influenced by the sex of the interacting partner. Ellis LL, et al. Genetics, 2011 Jan. PMID 20980240, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables metallopeptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
NOT enables peptidyl-dipeptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in proteolysis IKR
Inferred from Key Residues
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Ance-5
Names
Ance-5-PA
CG10142-PA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24888628..24891023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_133164.4 → NP_573392.2  Ance-5

    See identical proteins and their annotated locations for NP_573392.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95U59, Q9W0Z1
    Related
    FBpp0072325
    Conserved Domains (1) summary
    cl14813
    Location:93 → 610
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95U59 Q95U59
Q9W0Z1 Q9W0Z1

Gene LinkOut

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