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KIF3C kinesin family member 3C [ Homo sapiens (human) ]

Gene ID: 3797, updated on 7-Jun-2020

Summary

Official Symbol
KIF3Cprovided by HGNC
Official Full Name
kinesin family member 3Cprovided by HGNC
Primary source
HGNC:HGNC:6321
See related
Ensembl:ENSG00000084731 MIM:602845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 57.3), adrenal (RPKM 4.3) and 1 other tissue See more
Orthologs

Genomic context

See KIF3C in Genome Data Viewer
Location:
2p23.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (25926598..25982740, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (26149455..26205443, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ASXL transcriptional regulator 2 Neighboring gene prostaglandin E synthase 3 pseudogene 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 4 Neighboring gene ubiquinol-cytochrome c reductase hinge protein pseudogene 2 Neighboring gene tRNA methyltransferase subunit 11-2 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of kinesin family member 3C (KIF3C) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
motor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
intraciliary transport involved in cilium assembly TAS
Traceable Author Statement
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based movement TAS
Traceable Author Statement
more info
 
organelle transport along microtubule IEA
Inferred from Electronic Annotation
more info
 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
ciliary tip TAS
Traceable Author Statement
more info
 
cilium TAS
Traceable Author Statement
more info
 
cytosol TAS
Traceable Author Statement
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF3C
Names
KIF3C variant protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002254.8NP_002245.4  kinesin-like protein KIF3C

    See identical proteins and their annotated locations for NP_002245.4

    Status: VALIDATED

    Source sequence(s)
    AC013449, AC064847, KF456639
    Consensus CDS
    CCDS1719.1
    UniProtKB/Swiss-Prot
    O14782
    UniProtKB/TrEMBL
    A2RU78
    Related
    ENSP00000264712.3, ENST00000264712.8
    Conserved Domains (4) summary
    cd01371
    Location:9365
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam00225
    Location:16365
    Kinesin; Kinesin motor domain
    cd16269
    Location:538549
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:461569
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    25926598..25982740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264299.3XP_005264356.2  kinesin-like protein KIF3C isoform X1

    Conserved Domains (4) summary
    cd01371
    Location:9365
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam00225
    Location:16365
    Kinesin; Kinesin motor domain
    cd16269
    Location:538549
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:461569
    GBP_C; Guanylate-binding protein, C-terminal domain
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