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Start1 Start1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37927, updated on 5-Jul-2025
Official Symbol
Start1provided by FlyBase
Official Full Name
Start1provided by FlyBase
Primary source
FLYBASE:FBgn0035028
Locus tag
Dmel_CG3522
See related
AllianceGenome:FB:FBgn0035028
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3522; Dmel\CG3522; Start; start1; StART1
Summary
Predicted to enable cholesterol binding activity. Predicted to be involved in cholesterol transport and vesicle tethering to endoplasmic reticulum. Predicted to be active in endoplasmic reticulum-endosome membrane contact site and late endosome membrane. Predicted to colocalize with endoplasmic reticulum membrane. Is expressed in several structures, including dorsal ectoderm; dorsal epidermis primordium; gland; gonad; and nurse cell. Orthologous to several human genes including STARD3 (StAR related lipid transfer domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See Start1 in Genome Data Viewer
Location:
60D5-60D5; 2-107 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24574559..24577676)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20462082..20465199)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene unconventional prefoldin RPB5 interactor Neighboring gene TFIIF-interacting CTD phosphatase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SIFamide Neighboring gene piopio

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Drosophila gene Start1: a putative cholesterol transporter and key regulator of ecdysteroid synthesis. Roth GE, et al. Proc Natl Acad Sci U S A, 2004 Feb 10. PMID 14745013, Free PMC Article
  2. Case studies of ends-out gene targeting in Drosophila. Chen H, et al. Genesis, 2009 May. PMID 19298016
  3. The Fruit Fly Drosophila melanogaster as a Model System to Study Cholesterol Metabolism and Homeostasis. Niwa R, et al. Cholesterol, 2011. PMID 21512589, Free PMC Article
  4. New players in the regulation of ecdysone biosynthesis. Huang X, et al. J Genet Genomics, 2008 Jan. PMID 18222403
  5. br regulates the expression of the ecdysone biosynthesis gene npc1. Xiang Y, et al. Dev Biol, 2010 Aug 15. PMID 20621708

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. plays a key role in the regulation of ecdysteroid synthesis
    Title: The Drosophila gene Start1: a putative cholesterol transporter and key regulator of ecdysteroid synthesis.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cholesterol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vesicle tethering to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
colocalizes_with endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-endosome membrane contact site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
Start1
Names
CG3522-PA
CG3522-PB
CG3522-PC
CG3522-PD
Start1-PA
Start1-PB
Start1-PC
Start1-PD

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24574559..24577676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206217.3 → NP_995939.1  Start1, isoform B

    See identical proteins and their annotated locations for NP_995939.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W145
    Conserved Domains (2) summary
    pfam10457
    Location:57 → 232
    MENTAL; Cholesterol-capturing domain
    cl14643
    Location:247 → 360
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  2. NM_001259566.2 → NP_001246495.1  Start1, isoform C

    See identical proteins and their annotated locations for NP_001246495.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MZH4, Q9W145
    Conserved Domains (2) summary
    pfam10457
    Location:57 → 232
    MENTAL; Cholesterol-capturing domain
    cl14643
    Location:247 → 571
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  3. NM_138092.3 → NP_611936.2  Start1, isoform A

    See identical proteins and their annotated locations for NP_611936.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MZH4, Q9W145
    Related
    FBpp0088807
    Conserved Domains (2) summary
    pfam10457
    Location:57 → 232
    MENTAL; Cholesterol-capturing domain
    cl14643
    Location:247 → 571
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  4. NM_001299919.1 → NP_001286848.1  Start1, isoform D

    See identical proteins and their annotated locations for NP_001286848.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGM4
    Conserved Domains (1) summary
    cl14643
    Location:3 → 331
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGM4 A0A0B4LGM4
Q9W145.2 Q9W145

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