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rpl5.S ribosomal protein L5 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379064, updated on 5-Sep-2025
Official Symbol
rpl5.S
Official Full Name
ribosomal protein L5 S homeolog
Primary source
Xenbase:XB-GENE-6251827
Locus tag
XELAEV_18025391mg
See related
EnsemblRapid:ENSXLAG00005009550 AllianceGenome:Xenbase:XB-GENE-6251827
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
rpl5; rpl5-a; rpl5-b
Summary
Predicted to enable 5S rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to act upstream of or within translation. Predicted to be located in cytosolic ribosome and nucleolus. Predicted to be part of ribonucleoprotein complex. Is expressed in musculoskeletal system; nervous system; pharyngeal arch; and visual system. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 6; T-cell acute lymphoblastic leukemia; and glioblastoma. Orthologous to human RPL5 (ribosomal protein L5). [provided by Alliance of Genome Resources, Apr 2025]
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See rpl5.S in Genome Data Viewer
Location:
chromosome: 4S
Exon count:
8
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (83886785..83902043, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (77567330..77582861, complement)

Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene metal response element binding transcription factor 2 S homeolog Neighboring gene divergent protein kinase domain 1A S homeolog Neighboring gene ecotropic viral integration site 5 S homeolog Neighboring gene growth factor independent 1 transcription repressor S homeolog

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Binding site for Xenopus ribosomal protein L5 and accompanying structural changes in 5S rRNA. Scripture JB, et al. Biochemistry, 2011 May 10. PMID 21446704
  2. Developmental expression and 5S rRNA-binding activity of Xenopus laevis ribosomal protein L5. Wormington WM. Mol Cell Biol, 1989 Dec. PMID 2586520, Free PMC Article
  3. Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nishiyama A, et al. Nat Commun, 2020 Mar 6. PMID 32144273, Free PMC Article
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  5. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of the binding site for Xenopus ribosomal protein L5 and accompanying structural changes in 5S rRNA
    Title: Binding site for Xenopus ribosomal protein L5 and accompanying structural changes in 5S rRNA.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC52733

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables 5S rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in cytosolic ribosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
large ribosomal subunit protein uL18A
Names
60S ribosomal protein L5-A

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085908.1 → NP_001079377.1  large ribosomal subunit protein uL18A

    See identical proteins and their annotated locations for NP_001079377.1

    Status: PROVISIONAL

    Source sequence(s)
    BC041227
    UniProtKB/Swiss-Prot
    P15125
    UniProtKB/TrEMBL
    Q8AVX2
    Related
    ENSXLAP00005027900.1, ENSXLAT00005028637.1
    Conserved Domains (3) summary
    PTZ00069
    Location:1 → 295
    PTZ00069; 60S ribosomal protein L5; Provisional
    pfam00861
    Location:26 → 173
    Ribosomal_L18p; Ribosomal L18p/L5e family
    pfam14204
    Location:192 → 282
    Ribosomal_L18_c; Ribosomal L18 C-terminal region

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    83886785..83902043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15125.2 GenPept UniProtKB/Swiss-Prot:P15125

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials