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RBMY1J RNA binding motif protein Y-linked family 1 member J [ Homo sapiens (human) ]

Gene ID: 378951, updated on 22-Jul-2021

Summary

Official Symbol
RBMY1Jprovided by HGNC
Official Full Name
RNA binding motif protein Y-linked family 1 member Jprovided by HGNC
Primary source
HGNC:HGNC:23917
See related
Ensembl:ENSG00000226941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein likely functions as a splicing factor during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016]
Expression
Restricted expression toward testis (RPKM 5.5) See more
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Genomic context

See RBMY1J in Genome Data Viewer
Location:
Yq11.223
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (22403410..22419317)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (24549557..24563796)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein Y-linked family 2 member V, pseudogene Neighboring gene testis specific protein Y-linked 21, pseudogene Neighboring gene uncharacterized LOC101929148 Neighboring gene testis-specific transcript, Y-linked 6 Neighboring gene PTPN13 like Y-linked

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC166957, MGC178123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding motif protein, Y chromosome, family 1 member F/J
Names
Y chromosome RNA recognition motif 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_004755.2 

    Range
    592524..606763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001006117.4NP_001006117.2  RNA-binding motif protein, Y chromosome, family 1 member F/J

    See identical proteins and their annotated locations for NP_001006117.2

    Status: VALIDATED

    Source sequence(s)
    AC007320
    Consensus CDS
    CCDS35484.1
    UniProtKB/Swiss-Prot
    Q15415
    Related
    ENSP00000250831.5, ENST00000250831.5
    Conserved Domains (4) summary
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family
    cl28271
    Location:158316
    dnaA; chromosomal replication initiation protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    22403410..22419317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531500.1XP_011529802.1  RNA-binding motif protein, Y chromosome, family 1 member F/J isoform X1

    See identical proteins and their annotated locations for XP_011529802.1

    UniProtKB/TrEMBL
    J3KQ82
    Conserved Domains (4) summary
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    PRK14086
    Location:158316
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
  2. XM_017030059.1XP_016885548.1  RNA-binding motif protein, Y chromosome, family 1 member F/J isoform X3

  3. XM_011531503.1XP_011529805.1  RNA-binding motif protein, Y chromosome, family 1 member F/J isoform X2

    Conserved Domains (1) summary
    pfam08081
    Location:3478
    RBM1CTR; RBM1CTR (NUC064) family
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