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RBMY1E RNA binding motif protein Y-linked family 1 member E [ Homo sapiens (human) ]

Gene ID: 378950, updated on 11-Jun-2021

Summary

Official Symbol
RBMY1Eprovided by HGNC
Official Full Name
RNA binding motif protein Y-linked family 1 member Eprovided by HGNC
Primary source
HGNC:HGNC:23916
See related
Ensembl:ENSG00000242389
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 6.2) See more
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Genomic context

See RBMY1E in Genome Data Viewer
Location:
Yq11.223
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (21902177..21918044, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (24049765..24064174, complement)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377237 Neighboring gene RNA binding motif protein Y-linked family 1 member D Neighboring gene RNA binding motif protein Y-linked family 2 member A, pseudogene Neighboring gene OFD1 pseudogene 8 Y-linked

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding motif protein, Y chromosome, family 1 member E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_004755.2 

    Range
    92732..107141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001006118.3NP_001006118.2  RNA-binding motif protein, Y chromosome, family 1 member E

    See identical proteins and their annotated locations for NP_001006118.2

    Status: REVIEWED

    Source sequence(s)
    AC007322
    Consensus CDS
    CCDS35481.1
    UniProtKB/Swiss-Prot
    A6NEQ0
    Related
    ENSP00000372105.2, ENST00000382659.6
    Conserved Domains (3) summary
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    21902177..21918044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531494.3XP_011529796.1  RNA-binding motif protein, Y chromosome, family 1 member E isoform X2

    See identical proteins and their annotated locations for XP_011529796.1

    Conserved Domains (3) summary
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family
  2. XM_011531496.1XP_011529798.1  RNA-binding motif protein, Y chromosome, family 1 member E isoform X4

    Conserved Domains (1) summary
    pfam08081
    Location:3478
    RBM1CTR; RBM1CTR (NUC064) family
  3. XM_011531495.1XP_011529797.1  RNA-binding motif protein, Y chromosome, family 1 member E isoform X3

    Conserved Domains (3) summary
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family
  4. XM_011531493.1XP_011529795.1  RNA-binding motif protein, Y chromosome, family 1 member E isoform X1

    UniProtKB/TrEMBL
    J3KPK3
    Related
    ENSP00000372104.4, ENST00000382658.5
    Conserved Domains (3) summary
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family
  5. XM_017030058.1XP_016885547.1  RNA-binding motif protein, Y chromosome, family 1 member E isoform X5

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