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RBMY1D RNA binding motif protein Y-linked family 1 member D [ Homo sapiens (human) ]

Gene ID: 378949, updated on 11-Jun-2021

Summary

Official Symbol
RBMY1Dprovided by HGNC
Official Full Name
RNA binding motif protein Y-linked family 1 member Dprovided by HGNC
Primary source
HGNC:HGNC:23915
See related
Ensembl:ENSG00000244395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBM1; RBM2; YRRM1; YRRM2; hRBMY; RBMY1A1
Summary
This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein likely functions as a splicing factor during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016]
Expression
Restricted expression toward testis (RPKM 6.2) See more
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Genomic context

See RBMY1D in Genome Data Viewer
Location:
Yq11.223
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (21869718..21900746, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (24026223..24040673, complement)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377236 Neighboring gene OFD1 pseudogene 16 Y-linked Neighboring gene uncharacterized LOC105377237 Neighboring gene RNA binding motif protein Y-linked family 1 member E Neighboring gene RNA binding motif protein Y-linked family 2 member A, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding motif protein, Y chromosome, family 1 member D
Names
RNA-binding motif protein 1
RNA-binding motif protein 2
RNA-binding motif protein, Y chromosome, family 1 member A1
Y chromosome RNA recognition motif 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_004755.2 

    Range
    69190..83640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001006120.3NP_001006120.2  RNA-binding motif protein, Y chromosome, family 1 member D isoform 1

    See identical proteins and their annotated locations for NP_001006120.2

    Status: REVIEWED

    Source sequence(s)
    AC007322
    Consensus CDS
    CCDS35480.1
    UniProtKB/Swiss-Prot
    P0C7P1
    Related
    ENSP00000372127.1, ENST00000382680.5
    Conserved Domains (3) summary
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family
  2. NM_001320949.1NP_001307878.1  RNA-binding motif protein, Y chromosome, family 1 member D isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007322
    Consensus CDS
    CCDS83521.1
    UniProtKB/Swiss-Prot
    P0C7P1
    Related
    ENSP00000399181.2, ENST00000418956.2
    Conserved Domains (3) summary
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family
  3. NM_001320950.1NP_001307879.1  RNA-binding motif protein, Y chromosome, family 1 member D isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform 3, which has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC007322, BC144423
    Conserved Domains (3) summary
    COG0724
    Location:20165
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam08081
    Location:150194
    RBM1CTR; RBM1CTR (NUC064) family
    cl17169
    Location:1761
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    21869718..21900746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531487.3XP_011529789.1  RNA-binding motif protein, Y chromosome, family 1 member D isoform X2

    Conserved Domains (4) summary
    PHA02896
    Location:247362
    PHA02896; A-type inclusion like protein; Provisional
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family
  2. XM_011531488.3XP_011529790.1  RNA-binding motif protein, Y chromosome, family 1 member D isoform X3

    See identical proteins and their annotated locations for XP_011529790.1

    Conserved Domains (3) summary
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family
  3. XM_011531486.2XP_011529788.1  RNA-binding motif protein, Y chromosome, family 1 member D isoform X1

    See identical proteins and their annotated locations for XP_011529788.1

    UniProtKB/Swiss-Prot
    P0C7P1
    Conserved Domains (3) summary
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family
  4. XM_011531490.1XP_011529792.1  RNA-binding motif protein, Y chromosome, family 1 member D isoform X5

    See identical proteins and their annotated locations for XP_011529792.1

    UniProtKB/Swiss-Prot
    P0DJD3
    Conserved Domains (1) summary
    pfam08081
    Location:3478
    RBM1CTR; RBM1CTR (NUC064) family
  5. XM_011531489.1XP_011529791.1  RNA-binding motif protein, Y chromosome, family 1 member D isoform X4

    Conserved Domains (3) summary
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family
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